CEP120
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEP120, CCDC100, SRTD13, centrosomal protein 120, JBTS31
External IDsOMIM: 613446 MGI: 2147298 HomoloGene: 27415 GeneCards: CEP120
Orthologs
SpeciesHumanMouse
Entrez

153241

225523

Ensembl

ENSG00000168944

ENSMUSG00000048799

UniProt

Q8N960

Q7TSG1

RefSeq (mRNA)

NM_001166226
NM_153223

NM_178686

RefSeq (protein)

NP_848801

Location (UCSC)Chr 5: 123.34 – 123.42 MbChr 18: 53.81 – 53.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein of 120 kDa (Cep120), also known as coiled-coil domain-containing protein 100, is a protein that in humans is encoded by the CEP120 gene.[5][6]

Function

This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000168944 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048799 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: centrosomal protein 120kDa".
  6. Xie Z, Moy LY, Sanada K, Zhou Y, Buchman JJ, Tsai LH (October 2007). "Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool". Neuron. 56 (1): 79–93. doi:10.1016/j.neuron.2007.08.026. PMC 2642594. PMID 17920017.
  • Human CEP120 genome location and CEP120 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 120 kDa (CEP120)

Further reading


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