CLDN11
Identifiers
AliasesCLDN11, OSP, OTM, claudin 11, HLD22
External IDsOMIM: 601326 MGI: 106925 HomoloGene: 4093 GeneCards: CLDN11
Orthologs
SpeciesHumanMouse
Entrez

5010

18417

Ensembl

ENSG00000013297

ENSMUSG00000037625

UniProt

O75508

Q60771

RefSeq (mRNA)

NM_005602
NM_001185056

NM_008770

RefSeq (protein)

NP_001171985
NP_005593

NP_032796

Location (UCSC)Chr 3: 170.42 – 170.45 MbChr 3: 31.2 – 31.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene.[5][6][7] It belongs to the group of claudins and was the first member of the family to be knocked out in mice, thereby demonstrating the central role of claudins for intramembranous strands observed in freeze-fracture images.[8]

Function

The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function,[9] hearing,[10] and spermatogenesis.[8] There is growing evidence that the protein determines the permeability between layers of myelin sheaths[11] and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.[7] Finally, experiments in Cldn11-null mice demonstrate that behavioral phenotypes in open field tests, as well as defects in sound lateralization, accompany changes in neurotransmitter levels in the amygdala/ventral hippocampus and auditory brainstem. This study reveals a molecular mechanism by which changes to myelin membrane properties in the absence of degenerative pathology, could lead to neuropsychiatric disease in humans.[12]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000013297 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037625 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bronstein JM, Kozak CA, Chen XN, Wu S, Danciger M, Korenberg JR, Farber DB (June 1996). "Chromosomal localization of murine and human oligodendrocyte-specific protein genes". Genomics. 34 (2): 255–7. doi:10.1006/geno.1996.0278. PMID 8661061.
  6. Bronstein JM, Popper P, Micevych PE, Farber DB (September 1996). "Isolation and characterization of a novel oligodendrocyte-specific protein". Neurology. 47 (3): 772–8. doi:10.1212/wnl.47.3.772. PMID 8797478. S2CID 20873471.
  7. 1 2 "Entrez Gene: CLDN11 claudin 11 (oligodendrocyte transmembrane protein)".
  8. 1 2 Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, Brodie SE, Danias J, Bronstein JM, Kachar B, Lazzarini RA (December 1999). "CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice". Cell. 99 (6): 649–59. doi:10.1016/S0092-8674(00)81553-6. PMID 10612400. S2CID 10566754.
  9. Devaux J, Gow A (December 2008). "Tight junctions potentiate the insulative properties of small CNS myelinated axons". The Journal of Cell Biology. 183 (5): 909–21. doi:10.1083/jcb.200808034. PMC 2592840. PMID 19047465.
  10. Gow A, Davies C, Southwood CM, Frolenkov G, Chrustowski M, Ng L, Yamauchi D, Marcus DC, Kachar B (August 2004). "Deafness in Claudin 11-null mice reveals the critical contribution of basal cell tight junctions to stria vascularis function". The Journal of Neuroscience. 24 (32): 7051–62. doi:10.1523/JNEUROSCI.1640-04.2004. PMC 4615685. PMID 15306639.
  11. Denninger AR, Breglio A, Maheras KJ, LeDuc G, Cristiglio V, Demé B, Gow A, Kirschner DA (October 2015). "Claudin-11 Tight Junctions in Myelin Are a Barrier to Diffusion and Lack Strong Adhesive Properties". Biophysical Journal. 109 (7): 1387–97. Bibcode:2015BpJ...109.1387D. doi:10.1016/j.bpj.2015.08.012. PMC 4601091. PMID 26445439.
  12. Maheras KJ, Peppi M, Ghoddoussi F, Galloway MP, Perrine SA, Gow A (February 2018). "Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice". Scientific Reports. 8 (1): 3798. Bibcode:2018NatSR...8.3798M. doi:10.1038/s41598-018-22047-9. PMC 5830493. PMID 29491447.

Further reading


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