CLDN4
Identifiers
AliasesCLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R, claudin 4
External IDsOMIM: 602909 MGI: 1313314 HomoloGene: 1000 GeneCards: CLDN4
Orthologs
SpeciesHumanMouse
Entrez

1364

12740

Ensembl

ENSG00000189143

ENSMUSG00000047501

UniProt

O14493

O35054

RefSeq (mRNA)

NM_001305

NM_009903

RefSeq (protein)

NP_001296

NP_034033

Location (UCSC)Chr 7: 73.8 – 73.83 MbChr 5: 134.97 – 134.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins.

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.[5]

Claudin 4 can also be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma.[6] As a pancreatic cancer marker in cell-blocks of effusion specimens, it has also been found to have a superior performance to BerEp4 staining.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000189143 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047501 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CLDN4 claudin 4".
  6. Ohta Y, Sasaki Y, Saito M, Kushima M, Takimoto M, Shiokawa A, Ota H (2013). "Claudin-4 as a marker for distinguishing malignant mesothelioma from lung carcinoma and serous adenocarcinoma". Int J Surg Pathol. 21 (5): 493–501. doi:10.1177/1066896913491320. PMID 23775021. S2CID 6840615.
  7. Vojtek M, Walsh MD, Papadimos DJ, Shield PW (2019). "Claudin-4 immunohistochemistry is a useful pan-carcinoma marker for serous effusion specimens" (PDF). Cytopathology. 30 (6): 614–619. doi:10.1111/cyt.12765. PMID 31390089. S2CID 199468828.

Further reading


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