CLK3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLK3, PHPHCLK3/152, CDC like kinase 3
External IDsOMIM: 602990 MGI: 1098670 HomoloGene: 101534 GeneCards: CLK3
Orthologs
SpeciesHumanMouse
Entrez

1198

102414

Ensembl

ENSG00000179335

ENSMUSG00000032316

UniProt

P49761

O35492

RefSeq (mRNA)

NM_001130028
NM_001292
NM_003992

NM_007713

RefSeq (protein)

NP_001123500
NP_003983

NP_031739

Location (UCSC)Chr 15: 74.6 – 74.65 MbChr 9: 57.66 – 57.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene.[5][6] The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000179335 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032316 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Jan 1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J Mol Biol. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.
  6. Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501. S2CID 40593571.
  7. "Entrez Gene: CLK3 CDC-like kinase 3".

Further reading


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