CLTC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLTC, CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain, MRD56
External IDsOMIM: 118955 MGI: 2388633 HomoloGene: 3572 GeneCards: CLTC
Orthologs
SpeciesHumanMouse
Entrez

1213

67300

Ensembl

ENSG00000141367

ENSMUSG00000047126

UniProt

Q00610

Q68FD5

RefSeq (mRNA)

NM_001288653
NM_004859

NM_001003908
NM_001356393

RefSeq (protein)

NP_001275582
NP_004850

NP_001003908
NP_001343322

Location (UCSC)Chr 17: 59.62 – 59.7 MbChr 11: 86.59 – 86.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.[5][6]

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.[7]

Interactions

CLTC has been shown to interact with PICALM[8] and HGS.[9]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000141367 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047126 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV (Feb 1992). "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter". Genomics. 11 (1): 174–8. doi:10.1016/0888-7543(91)90115-U. PMID 1765375.
  6. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  7. "Entrez Gene: CLTC clathrin, heavy chain (Hc)".
  8. Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Mol. Biol. Cell. 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. ISSN 1059-1524. PMC 25500. PMID 10436022.
  9. Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (Sep 2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. ISSN 0261-4189. PMC 125612. PMID 11532964.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.