coronin, actin binding protein, 1B
Identifiers
SymbolCORO1B
NCBI gene57175
HGNC2253
OMIM609849
RefSeqNM_020441
UniProtQ9BR76
Other data
LocusChr. 11 q13.1
Search for
StructuresSwiss-model
DomainsInterPro

Coronin, actin binding protein, 1B also known as CORO1B is a protein which in humans is encoded by the CORO1B gene.[1] Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility.[2]

Function

A mammalian coronin enriches at the leading edge of migrating cells.[3] Studies related to this protein are as follows:

  • Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.[4]
  • F-actin binding is essential for coronin 1B function in vivo.[5]
  • Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.[6]
  • Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.[2]
  • In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.[7]
  • Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.[8]

References

  1. ↑ Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (September 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.
  2. 1 2 Cai L, Holoweckyj N, Schaller MD, Bear JE (September 2005). "Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility". J. Biol. Chem. 280 (36): 31913–23. doi:10.1074/jbc.M504146200. PMID 16027158.
  3. ↑ "Entrez Gene: CORO1B coronin, actin binding protein, 1B".
  4. ↑ Cai L, Makhov AM, Schafer DA, Bear JE (September 2008). "Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia". Cell. 134 (5): 828–42. doi:10.1016/j.cell.2008.06.054. PMC 2570342. PMID 18775315.
  5. ↑ Cai L, Makhov AM, Bear JE (May 2007). "F-actin binding is essential for coronin 1B function in vivo". J. Cell Sci. 120 (Pt 10): 1779–90. doi:10.1242/jcs.007641. PMID 17456547.
  6. ↑ Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE (March 2007). "Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge". Cell. 128 (5): 915–29. doi:10.1016/j.cell.2007.01.031. PMC 2630706. PMID 17350576.
  7. ↑ Di Giovanni S, De Biase A, Yakovlev A, Finn T, Beers J, Hoffman EP, Faden AI (January 2005). "In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury". J. Biol. Chem. 280 (3): 2084–91. doi:10.1074/jbc.M411975200. PMID 15522871.
  8. ↑ Parente JA, Chen X, Zhou C, Petropoulos AC, Chew CS (January 1999). "Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway". J. Biol. Chem. 274 (5): 3017–25. doi:10.1074/jbc.274.5.3017. PMID 9915840.


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