COX6B2
Identifiers
AliasesCOX6B2, COXVIB2, CT59, cytochrome c oxidase subunit 6B2
External IDsOMIM: 618127 MGI: 3044182 HomoloGene: 16948 GeneCards: COX6B2
Orthologs
SpeciesHumanMouse
Entrez

125965

333182

Ensembl

ENSG00000160471

ENSMUSG00000051811

UniProt

Q6YFQ2

Q80ZN9

RefSeq (mRNA)

NM_144613

NM_001289848
NM_001289849
NM_001289850
NM_183405
NM_183406

RefSeq (protein)

NP_653214
NP_001356727
NP_001356728
NP_001356729

NP_001276777
NP_001276778
NP_001276779
NP_899664
NP_899665

Location (UCSC)Chr 19: 55.35 – 55.35 MbChr 7: 4.75 – 4.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome c oxidase subunit VIb polypeptide 2 is a protein that in humans is encoded by the COX6B2 gene. Cytochrome c oxidase 6B2 is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain.[5]

Structure

The COX6B2 gene, located on the q arm of chromosome 19 in position 13.42, contains 5 exons and is 5,113 base pairs in length.[5] The protein encoded by the COX6B2 gene weighs 11 kDa and is composed of 88 amino acids.[6][7] The protein is a subunit of Complex IV, a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.[5]

Function

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane to drive ATP synthesis via protonmotive force. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex.[5]

Summary reaction:

4 Fe2+-cytochrome c + 8 H+in + O2 → 4 Fe3+-cytochrome c + 2 H2O + 4 H+out[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160471 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051811 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 4 "Entrez Gene: Cytochrome c oxidase subunit VIb polypeptide 2".
  6. ↑ Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
  7. ↑ "Cytochrome c oxidase subunit VIb polypeptide 2". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 2018-07-19. Retrieved 2018-07-18.
  8. ↑ Voet D, Voet JG, Pratt CW (2013). "Chapter 18". Fundamentals of biochemistry: life at the molecular level (4th ed.). Hoboken, NJ: Wiley. pp. 581–620. ISBN 978-0-470-54784-7.

Further reading

  • Taanman JW, Schrage C, Ponne NJ, Das AT, Bolhuis PA, de Vries H, Agsteribbe E (Sep 1990). "Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues". Gene. 93 (2): 285–91. doi:10.1016/0378-1119(90)90237-l. PMID 2172092.
  • Hüttemann M, Jaradat S, Grossman LI (Sep 2003). "Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c?". Molecular Reproduction and Development. 66 (1): 8–16. doi:10.1002/mrd.10327. PMID 12874793. S2CID 45002095.

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