CPN2

CPN2
Identifiers
Aliases	CPN2, ACBP, carboxypeptidase N subunit 2
External IDs	OMIM: 603104 MGI: 1919006 HomoloGene: 19487 GeneCards: CPN2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	194,351,328 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	30,086,317 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney; ; kidney tubule; ; right adrenal gland; ; glomerulus; ; metanephric glomerulus; ; left adrenal gland; ; retinal pigment epithelium; ; left ventricle; ; renal medulla;
	Top expressed in
	left lobe of liver; ; brown adipose tissue; ; sexually immature organism; ; yolk sac; ; aorta; ; duodenum; ; ascending aorta; ; jejunum; ; ureter; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme regulator activity; metallocarboxypeptidase activity;
Cellular component	blood microparticle; extracellular exosome; extracellular region; extracellular space; extracellular matrix;
Biological process	protein stabilization; regulation of catalytic activity; proteolysis; regulation of complement activation;
	Sources:Amigo / QuickGO
Orthologs
	1370
	71756
	ENSG00000178772
	ENSMUSG00000023176
	P22792
	Q9DBB9
	NM_001080513; NM_001291988; NM_001309
	NM_027904
	NP_001073982; NP_001278917
	NP_082180
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxypeptidase N subunit 2 is an enzyme that in humans is encoded by the CPN2 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178772 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023176 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tan F, Weerasinghe DK, Skidgel RA, Tamei H, Kaul RK, Roninson IB, Schilling JW, Erdos EG (Feb 1990). "The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats". J Biol Chem. 265 (1): 13–9. doi:10.1016/S0021-9258(19)40187-7. PMID 2378615.
↑ Riley DA, Tan F, Miletich DJ, Skidgel RA (Apr 1999). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1)". Genomics. 50 (1): 105–8. doi:10.1006/geno.1998.5295. PMID 9628828.
↑ "Entrez Gene: CPN2 carboxypeptidase N, polypeptide 2".

Human CPN2 genome location and CPN2 gene details page in the UCSC Genome Browser.

Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics. 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718. S2CID 29261009.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Skidgel RA, Bennett CD, Schilling JW, et al. (1988). "Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases". Biochem. Biophys. Res. Commun. 154 (3): 1323–9. doi:10.1016/0006-291X(88)90284-7. PMID 3408501.

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