CSNK1E
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCSNK1E, CKIepsilon, HCKIE, Casein kinase 1 isoform epsilon, casein kinase 1 epsilon, CKIe
External IDsOMIM: 600863 MGI: 1351660 HomoloGene: 121695 GeneCards: CSNK1E
Orthologs
SpeciesHumanMouse
Entrez

1454

27373

Ensembl

ENSG00000213923

ENSMUSG00000022433

UniProt

P49674

Q9JMK2

RefSeq (mRNA)

NM_001894
NM_152221

NM_013767
NM_001289898
NM_001289899
NM_001359862
NM_001359863

RefSeq (protein)

NP_001885
NP_689407

NP_001276827
NP_001276828
NP_038795
NP_001346791
NP_001346792

Location (UCSC)Chr 22: 38.29 – 38.32 MbChr 15: 79.3 – 79.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.[5][6]

Function

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene.[7]

Interactions

CSNK1E has been shown to interact with PER1[8] and AXIN1.[9]

Inhibitors

Selective
Non-selective
  • PF-670462 (also inhibits CK1-δ)

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000213923 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022433 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (Jun 1995). "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". The Journal of Biological Chemistry. 270 (25): 14875–83. doi:10.1074/jbc.270.25.14875. PMID 7797465.
  6. Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (Oct 1999). "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function". Proceedings of the National Academy of Sciences of the United States of America. 96 (22): 12548–52. doi:10.1073/pnas.96.22.12548. PMC 22983. PMID 10535959.
  7. "Entrez Gene: CSNK1E casein kinase 1, epsilon".
  8. Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM (Jul 2000). "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon". Molecular and Cellular Biology. 20 (13): 4888–99. doi:10.1128/MCB.20.13.4888-4899.2000. PMC 85940. PMID 10848614.
  9. Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.
  • Human CSNK1E genome location and CSNK1E gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Casein kinase I isoform epsilon (CSNK1E)
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