Cytochrome P450, family 13, also known as CYP13, is a nematoda cytochrome P450 monooxygenase family.[1] The first gene identified in this family is the CYP13A1 from the Caenorhabditis elegans.
CYP13 can be divided into subfamily CYP13A and CYP13B,[1] and the CYP13B was named CYP16 family at the beginning of its discovery, which have been discontinued and been changed to the current name, because its genetic relationship with the subfamily CYP13A.[2]
Genes in C. elegans
| Gene | Biological Functions | Protein Length[1] | Ref |
|---|---|---|---|
| CYP13A1 | 519 | ||
| CYP13A2 | 515 | ||
| CYP13A3 | 520 | ||
| CYP13A4 | 520 | ||
| CYP13A5 | Dauer formation | 520 | |
| CYP13A6 | 518 | ||
| CYP13A7 | Dauer formation, Detoxication | 518 | |
| CYP13A8 | Acidic Stress | 509 | [3] |
| CYP13A9 | pseudogene | ||
| CYP13A10 | 519 | ||
| CYP13A11 | 517 | ||
| CYP13A12 | Lipid metabolism | 518 | [4] |
| CYP13B1 | 510 | ||
| CYP13B2 | 511 | ||
References
- 1 2 3 Larigot, L; Mansuy, D; Borowski, I; Coumoul, X; Dairou, J (22 February 2022). "Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics". Biomolecules. 12 (3): 342. doi:10.3390/biom12030342. PMC 8945457. PMID 35327534.
- ↑ Nelson, DR (November 1998). "Metazoan cytochrome P450 evolution". Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology. 121 (1–3): 15–22. doi:10.1016/s0742-8413(98)10027-0. PMID 9972448.
- ↑ Cong, Yanyi; Yang, Hanwen; Zhang, Pengchi; Xie, Yusu; Cao, Xuwen; Zhang, Liusuo (10 September 2020). "Transcriptome Analysis of the Nematode Caenorhabditis elegans in Acidic Stress Environments". Frontiers in Physiology. 11: 1107. doi:10.3389/fphys.2020.01107. PMC 7511720. PMID 33013473.
- ↑ Keller, J; Ellieva, A; Ma, DK; Ju, J; Nehk, E; Konkel, A; Falck, JR; Schunck, WH; Menzel, R (15 November 2014). "CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation" (PDF). The Biochemical Journal. 464 (1): 61–71. doi:10.1042/BJ20140848. PMID 25138176.
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