Season 1

The season centers on Grachi (Isabella Castillo), a witch and a new student in Escolarium. She deals with using her magic and trying to find out how to defeat the Principal (an evil witch who tries to steal the powers of Grachi so she can be the most powerful witch). Grachi also deals with her rival, Matilda (Kimberly Dos Ramos) with whom she fights for the love of Daniel (Andrés Mercado). At the end of the season, Matilda celebrates her 16th birthday at the night of the eclipse while the Principal (Martha Pabon) and Sibilo (William Valdes) plan to steal the powers of Matilda and Grachi. The two girls team up and fight the Principal, turning her into a dog, but losing their powers. Matilda finally realizes that Grachi and Daniel are meant to be together.

Season 2

A new witch named Mia arrives in town. Unfortunately, she falls in love with Daniel, Grachi's boyfriend. So she manipulates Grachi into a false friendship in order to win over Daniel (who is not insensitive to her charms).

Along with Mia comes the Witches' Council, who remind Grachi of his responsibilities. But one of them has evil intentions towards Grachi and wants to win the heart of Francisco, who is Mathilda's mother along with Ursula. Mathilda, for her part, enters into an intermittent relationship with Diego and wants her powers back.

At the end of the season, Grachi dreams of a mysterious boy to whom she seems close: Axel.

Season 3

Grachi's life is turned upside down the day she meets a young wizard: Axel Velez, who will become both her lover and her enemy. Grachi starts school at the wizards' college that Tony had told her about. There, Grachi learns much more about her role as a chosen one, while her heart is caught between her human and witch life, and her relationships with Daniel, her first love, and Axel, her newfound love.

Main

• Isabella Castillo as Graciela "Grachi" Alonso – A new 16-year-old student at Escolarium, she is a very powerful witch who has inherited her powers from her late mother. At the beginning of season one, she moves to a new neighborhood with her father Francisco, who is the new math professor at Escolarium. Her best friend is Mecha, while she is in love with Daniel. During the second season, Grachi gets a new enemy named Mía, a witch who is determined to steal Daniel's love from her. At the end of the second season, Grachi's powers get stronger, enough to defeat Mía. During the third season, she has a new love interest who is also her enemy, Axel.
• Andrés Mercado as Daniel Esquivel – The leader of the swimming team "The Sharks" at Escolarium. He's Chema's cousin and best friend. Daniel's parents are Cristina and Ricardo, and he has three siblings: Melanie, Luis and Roberto. He's introduced as Matilda's boyfriend and the most popular boy in the school, who every girl wants to be with. He and Grachi start a relationship during the first season's last episodes. In season two, he and Leo become enemies, because both want to be with Grachi. During the third season, Daniel befriends Leo, as he faces a new enemy, Axel.
• Kimberly Dos Ramos as Matilda Román (Seasons 1–2) – She's the main antagonist of the first season and was the most popular girl at Escolarium before Grachi's arrival. She is also a witch but uses her powers to do bad. She is the leader of the "Red Panthers", a group of girls who dance and respond to all of Matilda's manipulations. Matilda is Daniel's ex-girlfriend, and she is determined to win his love back and destroy Grachi. During the second season, she began dating a new guy named Diego. She and Grachi developed a slight friendship during the season and became stepsisters at the end due to Ursula and Francisco's wedding. Matilda doesn't return for the third season.
• Rafael de la Fuente as Diego Forlán – Part of "The Sharks", Matilda's boyfriend in season two and a Kanay, a person who can manipulate the four elements. He was a minor character during the first season and got a prominent role during the following ones. In the third season, he falls in love with Axel's sister, Amaya, and she becomes his girlfriend at the end of the third season.
• Mauricio Henao as Antonio "Tony" Gordillo – A highly intelligent and nerdy boy who falls in love with Grachi, but his affections aren't reciprocated. He joins the swimming team "The Sharks". At the end of the first season, Tony wins a scholarship to study at a better school and leaves Escolarium in search of new opportunities. He returns for the second and third season as a guest star, revealing he's a wizard. During the second season, he doesn't wear his glasses anymore, and has a more mature look. During the third season, he becomes an antagonist, trying to destroy Grachi for not loving him back, but he is locked up in a magical powder box by Axel.
• Sol Rodríguez as Mercedes "Mecha" Estevez – Grachi's best friend, daughter of Lolo. She hates Matilda, but is stuck living in the same house as her because Lolo works for Ursula, Matilda's mother. Mecha is in love with Chema. In season 2, she moves out of Matilda's mansion with her mother. She also dislikes Mía but becomes her guardian after finding out that the evil witches are the ones who have guardians, while the good witches only have magical tutors to guide them. In the third season, she falls in love with Manú.
• Lance Dos Ramos as José María "Chema" Esquivel (Seasons 1–2) – Daniel's cousin and best friend, part of "The Sharks". Chema's parents are artists who tour most of the time, so Chema lives with his uncle Ricardo and aunt Cristina and his four cousins. He is in love with Mecha. He doesn't appear in the third season.
• Maria Gabriela de Faría as Mía Novoa (Seasons 2–3) – The new witch at Escolarium and Grachi's enemy in the second season. She falls in love with Daniel right away, but her love is not reciprocated. In the last episode of the second season, she tries to destroy Grachi's father and Matilda's mother wedding for revenge. She is later enchanted and loses her memory. During season three, she takes her memory back and tries to take revenge, but in the end she befriends Grachi.
• Willy Martin as Leonardo "Leo" Martinez (Seasons 2–3) – An intelligent and creative guy who uses science to create his own magic. He has a crush on Grachi and hates Daniel. During the third season, he befriends Daniel and starts a relationship with his best friend Valeria.
• Danilo Carrera as Axel Vélez (Seasons 2–3) – A wizard at the school of witchcraft, he is Amaya's brother, Erick's son and Mía's ex-boyfriend. He's the villain of the third season and uses his power to do misdeeds. He is sent to the past in the season's last episode by Daniel through the collar.
• Jesús Neyra as Manú (Season 3) – used to be Axel's best friend and sidekick. He falls in love with Mecha, and later becomes part of the heroes and Mecha's boyfriend.
• Katie Barberi as Úrsula – Matilda's mother and Francisco's wife. She accidentally obtained Matilda's powers during the final episode of the first season and the first ones of the second one. She gets closer to Grachi and Francisco during the second season. She marries Francisco at the end of the season. Note: Barberi also played Ursula (Maddie Van Pelt's mom) in Every Witch Way.
• Ramiro Fumazoni as Francisco Alonso – Grachi's father and, later, new principal of the Escolarium and Úrsula's husband.
• Sharlene Taulé as Katty – Co-leader of the "Red Panthers" and Matilda's sidekick. Dotty and Betty's best friend.
• María del Pilar Pérez as Dotty – Member of the "Red Panthers" and Matilda's sidekick. Katty and Betty's.
• Carlos Arrechea aka Carlo Arrechea as Sebastian (Seasons 1–3) – Member of "The Sharks", the popular swimming team from Escolarium. He's funny and likes to be the center of attention, burps all the time specially on season 3. His nickname is "El Tiburón Peligroso" (The dangerous shark). He always wants to be the best. His best friend is Carlos. He is intelligent, naive and a good athlete.
• Alexandra Pomales as Betty (Season 1) – Member of the "Red Panthers" and Matilda's sidekick. Betty transfers to a different school during the first season.
• Cristian Campocasso as Luis Esquivel – Daniel's younger brother.
• Evaluna Montaner as Melanie Esquivel (Seasons 1–2) – Daniel's younger sister. Like her brothers, she likes Grachi and wants her to be Daniel's girlfriend.
• Andrés Cotrino as Roberto Esquivel (Seasons 1–2) – Daniel's younger brother.
• Liannet Borrego as Cussy Canosa (Season 1) – Julio's girlfriend, secretary in Escolarium and Grachi's magic tutor.
• Lino Martone as Julio Vallas (Season 1) – Cussy's boyfriend, and the son of the Principal. He used to be "The Sharks" team coach, but later resigned during the second season.

Recurring

• Marisela González as Lolo (Seasons 1–2) – Mecha's mother and Úrsula's personal assistant only in season one. In season two, she leaves Úrsula's house and goes to an apartment with her daughter Mecha. She was the guardian of Ora.
• William Valdes as Sibilo/Ora Santisteban (Season 1) – Lolo's ring, former wizard and Oracle.
• Adriana Cataño as Cristina de Esquivel (Seasons 1–2) – Daniel's mother.
• Manuel Carrillo as Ricardo Esquivel – Daniel's father.
• Virginia Nuñez as Kim Kanay(Seasons 2–3) – Diego's friend and a Kanay.
• Martha Pabón as Mrs. Director (Season 1) – Principal of Escolarium and main antagonist in season one.
• Nicole Apollonio as Diana (Season 1–2) – Friend of Melanie and Guillermo's sister.
• Raquel Rojas as Rosa Forlán – Leader of the pink gossips, Diego's sister and also Guillermo's girlfriend during the second and third season.
• Wendy Regalado as Lucía – Member of the pink gossips. She is in love with Tony.
• Erika Navarro as Veronica (Season 1) – Member of the pink gossips.
• Andreina Santander as Marta (Season 1) – Member of the pink gossips.
• Elizabeth Lazo as Carolina (Season 1) – Member of the pink gossips.
• Angela Rincon as Silvia – Member of the pink gossips.
• Ana Carolina Grajales as Valeria (Seasons 2–3) – Member of the pink gossips. Leo's assistant and girlfriend in season three. She's Amaya's clone.
• Ana Carolina Grajales as Amaya Vélez (Season 3) – A new witch in the third season. Axel's sister, Mía's best friend, she falls in love with Diego, who is a Kanay and currently is her boyfriend at the end of the third season.
• Guilherme Apollonio as Guillermo – Member of "The Sharks". He had a crush on Grachi only in the first season. Diego's best friend and Rosa's boyfriend during the second and third season.
• Tony Hernandez as Carlos – Member of "The Sharks".
• Jesus Licciardello as Eduardo (Season 1) – Dotty's lizard which was temporarily turned human by Matilda.
• Alex Rosguer as Miguel (Season 1–2) – Leader of "The Dolphins" and Daniel's rival. He has a much bigger role during the second season, trying to take Grachi away from Daniel.
• Paloma Marquez as Isadora (Season 1) – Dance teacher at Escolarium.
• Yosvany Morales as Teacher of Chemistry (Season 1) – Teacher at Escolarium.
• Francisco Chacin as Fernando Gordillo – Tony's father and worker of the Cafeteria at Escolarium.
• Diana Osorio as Alejandra Forlán (Season 2) – She is the new coach of "The Sharks", and she is the sister of Diego and Rosa.
• Juan Pablo Llano as Ignacio "Nacho" Novoa (Season 2) – Mia's brother. He is the new coach of "The Dolphins" in season two and is in love with Alejandra.

Wonderfully Magical Story

Wonderfully Magical Story is the first special of the series, which premiered on May 2, 2011, before the release of the series. This special was a presentation of the characters and the content of the series. It only showed the first season presentation. It has been released on April 28, 2011.

Unpublished episode

This is a TV special containing some deleted scenes. It has been released on August 19, 2011. Principally, the episode focuses on Diego and his powers.

Quiero Mis 16

It's a fictional story, set during the preparations for Matilda's sixteenth birthday. It has been released on August 25, 2011.

Life's Wonderfully Magical, Volume 1

The soundtrack of the first season was released in Latin America on June 7, 2011. The album includes 14 songs used in the series sang mostly by Isabella Castillo, some others of the cast and Latin artists. The simple theme of the series was released on April 1, 2011, with its accompanying video. The second single from the album, Tu Eres Para Mi, was released on July 21, 2011. Distributed by Universal Music and Warner Music. A live concert tour was created to promote the album in North America, South America and Europe. The album peaked No. 1 in Mexico and achieved a diamond certification in that country.

Life's Wonderfully Magical, Volume 2

The second soundtrack was released on April 11, 2012, in Latin America and it contains the season 2 songs, this time all sang by the entire cast from the series. Distributed by Warner Music. A live concert tour was created to promote the album in North America, South America and Europe. The song "Lagrimas" won a Latin Grammy nomination. This album peaked No. 1 in 14 countries.

Soñar No Cuesta Nada

On March 21, 2013, Warner Music signed Nickelodeon Latin American star Isabella Castillo. The album served as the soundtrack of the third season, still Nickelodeon released also another third season soundtrack with different artists digitally. Soñar No Cuesta Nada was released on Latin America on April 23, 2013. This album peaked No. 14 in the Billboard Latin Hot 100. This also contains a new version of the Latin Grammy nominated song from Grachi season 2 "Lagrimas".