Carlos Federico López Restrepo
López in 2019 at Vanderbilt University
Born1975 (age 48–49)
Bogotá, Colombia
NationalityColombian-American
Education
  • B.Sc. in Chemistry/Biochemistry, B.L.A. in Liberal Arts 1998
  • Ph.D. in Physical Chemistry 2004
Alma mater
Awards
  • National Science Foundation CAREER Award (2019)
  • Vanderbilt CQS Pilot Award (2015)
  • Vanderbilt Provost Office, Outstanding URM Faculty Accomplishments Award (2015)
  • UK-US Consular Collaboration Development Award (2013)
Scientific career
FieldsSystems biology, Biophysics, Computational Modeling, Mathematical Modeling
Institutions
ThesisStudies of membrane and membrane protein systems using molecular dynamics simulations (2004)
Doctoral advisorMichael L. Klein
Other academic advisors
  • Peter J. Rossky
  • Peter K. Sorger

Carlos Federico López Restrepo (born 1975) is a Colombian-American scientist who researches network-driven biological processes using computational tools. Until March 2022, López was an Associate Professor of Biochemistry & Pharmacology & Biomedical Informatics & Mechanical Engineering at Vanderbilt University. He is currently a Principal Scientist and the Multiscale Modeling Lead at Altos Labs.

Early life and education

López was born in Bogotá, Colombia. He graduated from Colegio San Carlos, a primary and secondary private Catholic school in Bogotá.[1]

López graduated from University of Miami with a B.Sc. in Chemistry and Biochemistry, and a B.L.A. in Liberal Arts in 1998. In 2004 he obtained a Ph.D. in Physical Chemistry under the supervision of Michael L. Klein in the University of Pennsylvania.[2] He was also postdoctoral fellow in chemistry at the Center for Computational Molecular Sciences of the University of Texas at Austin and research fellow in systems biology at the Harvard Medical School.[3][4]

Career

López lead a namesake laboratory in Vanderbilt University in the department of biochemistry with the goal of “developing and applying numerical, modeling, and statistical methods to understand cellular processes and their dysregulation.” [5][6]

Under his 2019 National Science Foundation CAREER award López investigated the underpinnings for essential biochemical processes.[7] In 2017 he was named Vanderbilt’s liaison to Oak Ridge National Laboratory.[8]

López has published more than forty papers and has done numerous presentations in academic and scientific conferences. His work has been cited in thousands of publications.[9][10][11][12]

In 2021 López was promoted to the rank of Associate Professor at Vanderbilt University. In 2022, López moved to Altos Laboratories to study cellular processes associated with aging.

Software development

The López lab has contributed to various software tools used in systems biology including:

  • PySB a modeling framework to encode cellular biochemical processes in Python.
  • PyDREAM a Python implementation of the DREAM algorithm for Bayesian parameter inference.
  • MAGINE a modeling framework for multi-omics data integration.
  • PyViPR a visualization tool for dynamic biochemical processes with automated network resolution representation.

All tools from the Lopez lab can be found at the Lopez lab website on GitHub.

References

  1. ↑ Colegio San Carlos Yearbook Class of 1993, retrieved 2022-01-22
  2. ↑ Lopez, Carlos F (2004). Studies of membrane and membrane protein systems using molecular dynamics simulations (Thesis). OCLC 244974242.
  3. ↑ Lopez, Carlos F.; Darst, Richard K.; Rossky, Peter J. (1 May 2008). "Mechanistic Elements of Protein Cold Denaturation". The Journal of Physical Chemistry B. 112 (19): 5961–5967. doi:10.1021/jp075928t. PMID 18181599.
  4. ↑ Lopez, Carlos F.; Fire, Emiko; Keating, Amy; Sorger, Peter K. (February 2009). "Modeling Extrinsic Apoptosis Regulatory Network Pathways Using A Rules-based Framework". Biophysical Journal. 96 (3): 304a. Bibcode:2009BpJ....96R.304L. doi:10.1016/j.bpj.2008.12.1516.
  5. ↑ "Lopez lab develops computational tools to further understanding of complex biological systems". Vanderbilt University. January 20, 2022. Retrieved 2022-01-20.
  6. ↑ "Dr. Carlos F. Lopez | Using HPC simulations of biological systems to understand and treat cancer". IBM Developer. Archived from the original on 2022-01-20. Retrieved 2022-01-20.
  7. ↑ "NSF Award Search: Award # 1942255 - CAREER: Stochastic Biochemical Network Processes in Cellular Commitment to Fate". www.nsf.gov. Retrieved 2022-01-20.
  8. ↑ Communications, VUMC News and. "Lopez named Vanderbilt's liaison to Oak Ridge National Laboratory". Vanderbilt University. Retrieved 2022-01-22.
  9. ↑ "Search Results | bioRxiv". www.biorxiv.org. Retrieved 2022-01-20.
  10. ↑ Search Results for author Lopez CF on PubMed.
  11. ↑ "Carlos F Lopez". scholar.google.com. Retrieved 2022-01-20.
  12. ↑ "ORCID". orcid.org. Retrieved 2022-01-20.
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