CDC42EP5
Identifiers
Aliases	CDC42EP5, Borg3, CEP5, CDC42 effector protein 5
External IDs	OMIM: 609171 MGI: 1929745 HomoloGene: 10984 GeneCards: CDC42EP5
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,465,026 bp[1] End 54,473,296 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,154,259 bp[2] End 4,167,859 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum prostate rectum ascending aorta tibial nerve canal of the cervix Achilles tendon minor salivary gland urinary bladder right lung Top expressed in intestinal villus duodenum epithelium of stomach mucous cell of stomach large intestine pyloric antrum colon crypt of lieberkuhn of small intestine left colon belly cord More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity Cellular component cytosol cytoskeleton endomembrane system membrane plasma membrane cytoplasm Biological process JNK cascade positive regulation of pseudopodium assembly positive regulation of actin filament polymerization regulation of cell shape positive regulation of GTPase activity Rho protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 148170 58804 Ensembl ENSG00000167617 ENSMUSG00000063838 UniProt Q6NZY7 Q9Z0X0 RefSeq (mRNA) NM_145057 NM_021454 RefSeq (protein) NP_659494 NP_067429 Location (UCSC) Chr 19: 54.47 – 54.47 Mb Chr 7: 4.15 – 4.17 Mb PubMed search [3] [4]
Wikidata
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CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene. ^[5]

Function

Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013].

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.