Chi Van Dang

Chi Van Dang is a hematological oncologist and researcher, currently serving as the Scientific Director of Ludwig Institute for Cancer Research.[1] He is known for his research on genetics, the MYC gene and the cellular energy metabolism of cancer.

Dang has served as president of the American Society for Clinical Investigation.[2] He has been elected to the National Academy of Medicine,[2] the American Association for Cancer Research,[3] the American Academy of Arts and Sciences,[4] the American Society for Clinical Investigation,[2] and the Association of American Physicians,[5] among others.

Early life and academics

Chi Van Dang was born in Saigon, Vietnam[6] as one of ten children.[7] Dang's father was Chieu Van Dang, Vietnam's first neurosurgeon and was once the dean of the University of Saigon School of Medicine.[1][7]

After arriving in the United States in 1967, Dang completed his B.S. degree in Chemistry at the University of Michigan in 1975,[2] his Ph.D in chemistry at Georgetown University in 1978, and M.D. from Johns Hopkins University, in 1982.[7][8] At the University of California, San Francisco, he completed a fellowship on Hematology-Oncology training where he began to work with the MYC gene.[9]

Career

In 1987, Dang returned to Johns Hopkins where he took a faculty position. He was Director of the Division of Hematology at Johns Hopkins Hospital from 1993-2003.[10] He also served as Johns Hopkins Family Professor in Oncology Research. As of 2002, he became Vice Dean for Research,[11] and Director of the Johns Hopkins Institute for Cell Engineering.[12][7]

From 2002 to 2003, Dang was the President of the American Society for Clinical Investigation.[2] In his 2003 presidential address, he remarked, "I wish to remind all of us of the power of healing. Be it in the laboratory, at the cageside, bedside or computerside, we, as physicians, all have the ability to heal."[13]

As of September 1, 2011, Dang became the John H. Glick Professor of Medicine[14] and the Director of the Abramson Cancer Center at the University of Pennsylvania.[11]

As of July 1, 2017, Dang became the Scientific Director of the Ludwig Institute for Cancer Research, with the responsibility of overseeing the Institute's scientific strategy for studying the prevention, diagnosis, and treatment of cancer.[12] The Ludwig Institute has branches in the United States, Switzerland, and the United Kingdom.[7] He was also appointed a professor at the Wistar Institute on the campus of the University of Pennsylvania, which hosts the Ludwig Laboratory during his tenure as The Ludwig Institute's Scientific Director.[15][16]

In 2018, Dang became Editor-in-Chief of Cancer Research, a peer-reviewed scientific journal published by the American Association for Cancer Research. He published his first editorial in January.[17][18]

Research

Dang's research has focused on cancer cells and genetics, notably on energy utilization of cancer cells.[7] Research Dang's laboratories has contributed to the understanding of the function of the MYC a gene associated with different cancers.[7][19] Dang has examined the mechanisms and molecular signaling pathways governing the metabolism of cancer. By first establishing the mechanistic link between MYC and cellular energy metabolism, he identified the MYC gene as a master regulator of cell proliferation and cellular metabolism. This research has contributed to the idea that genetic alterations re-program the energy utilization of tumors and specialize cancer cells to rely on specific fuel sources.[19][7][4] This work may help to explain the Warburg effect. Disrupting communication signalling pathways in cancer cells is a possible strategy for the development of drugs to battle cancer.[20][21]

Eric Fearon conducted his postdoctoral research in Dang's laboratory, where he developed a system for the study of protein-protein interactions in living mammalian cells.[22]

Dang is also a proponent of chronotherapy, the idea that the delivery of drugs can be timed to take advantage of the body’s natural 24-hour rhythms, to minimize side effects and maximize treatment effectiveness. The National Cancer Institute has begun to support research into the function and regulation of clock genes and interactions between circadian rhythms, diseases, and treatments.[1][23][24]

Awards

References

  1. 1 2 3 Dolgin, Elie (1 May 2018). "How to ruin cancer's day". Knowable Magazine. doi:10.1146/knowable-050118-014201. Retrieved 8 August 2022.
  2. 1 2 3 4 5 6 7 "Chi Van Dang, MD, PhD". The American Society for Clinical Investigation. Retrieved November 13, 2021.
  3. 1 2 "Ludwig Cancer Research". April 4, 2018. Retrieved 9 August 2022.
  4. 1 2 3 "Chi Van Dang". American Academy of Arts & Sciences. November 11, 2021. Retrieved November 13, 2021.
  5. 1 2 3 "Chi Van Dang, MD, PhD". American Association for Cancer Research (AACR). Retrieved 9 August 2022.
  6. ↑ "Monographs Editor: Chi Van Dang". Genes & Cancer. 1 (6): 525. 1 June 2010. doi:10.1177/1947601910378525. ISSN 1947-6019. PMC 3092226. PMID 21779456.
  7. 1 2 3 4 5 6 7 8 "Ludwig Cancer Research". Ludwig Cancer Research. Retrieved November 13, 2021.
  8. ↑ "Chi Van Dang - Faculty - About Us - Perelman School of Medicine at the University of Pennsylvania". Perelman School of Medicine. Retrieved November 13, 2021.
  9. ↑ "Chi Van Dang, M.D., Ph.D." The Wistar Institute. July 27, 2018. Archived from the original on December 1, 2020. Retrieved November 13, 2021.
  10. ↑ "Professor Văn-Chí Đặng". VinFuture Prize Foundation. Retrieved 9 August 2022.
  11. 1 2 Perelman School of Medicine at the University of Pennsylvania (27 June 2011). "Cancer Genetics Expert Chi Van Dang to Lead Penn Medicine's Abramson Cancer Center". News Wise. Retrieved 9 August 2022.
  12. 1 2 "AACR Congratulates Dr. Chi Van Dang on His Appointment as Scientific Director of the Ludwig Institute for Cancer Research | PressReleasePoint". Press Release Point. American Association for Cancer Research. December 22, 2016. Retrieved 9 August 2022.
  13. ↑ Dang, Chi Van (2004). "Celebrating the physician-scientist". Cancer Research. The Journal of clinical investigation. S1 (2).
  14. 1 2 "Researchers Behind the Journals: Researcher Profile Chi Van Dang". aacrjournals.org. Retrieved 9 August 2022.
  15. ↑ "Chi Van Dang, MD, PhD, Appointed Professor at the Wistar Institute - The ASCO Post". The ASCO Post. August 25, 2017. Retrieved 9 August 2022.
  16. ↑ "Chi Van Dang, MD, PhD, appointed professor at The Wistar Institute". Healio. July 10, 2017. Retrieved November 13, 2021.
  17. ↑ Dang, Chi Van (December 1, 2017). "Convergence to Cure Cancer through Research: A Message from the New Editor-in-Chief". Cancer Research. American Association for Cancer Research (AACR). 78 (1): 3–4. doi:10.1158/0008-5472.can-17-3771. ISSN 0008-5472. PMID 29298804.
  18. ↑ "Chi Van Dang, MD, PhD Named Editor-in-Chief of Cancer Research - The ASCO Post". The ASCO Post. January 25, 2018. Retrieved 9 August 2022.
  19. 1 2 "Faculty - Abramson Family Cancer Research Institute". Perelman School of Medicine at the University of Pennsylvania. Retrieved November 13, 2021.
  20. ↑ Apple, Sam (12 May 2016). "An Old Idea, Revived: Starve Cancer to Death". The New York Times.
  21. ↑ Camarda, Roman; Williams, Jeremy; Goga, Andrei (2017). "In vivo Reprogramming of Cancer Metabolism by MYC". Frontiers in Cell and Developmental Biology. 5: 35. doi:10.3389/fcell.2017.00035. ISSN 2296-634X. PMC 5386977. PMID 28443280.
  22. ↑ "Society of Scholars Inducts New Members". Johns Hopkins University. May 14, 2007. Retrieved June 27, 2021.
  23. ↑ Walton, Zandra E.; Altman, Brian J.; Brooks, Rebekah C.; Dang, Chi V. (4 March 2018). "Circadian Clock's Cancer Connections". Annual Review of Cancer Biology. 2 (1): 133–153. doi:10.1146/annurev-cancerbio-030617-050216. ISSN 2472-3428. S2CID 91120424. Retrieved 9 August 2022.
  24. ↑ Kreier, Freda (22 June 2022). "These cancer cells wake up when people sleep". Nature. doi:10.1038/d41586-022-01724-w. Retrieved 9 August 2022.
  25. ↑ Wasta, Vanessa (June 8, 2012). "Cancer Genetics Expert Honored by Johns Hopkins Alumni Association - 06/08/2012". Johns Hopkins Medicine. Retrieved 9 August 2022.
  26. 1 2 Simpkins, Beth. "Three JHU Researchers Elected to Institute of Medicine". Johns Hopkins Medicine. Retrieved 9 August 2022.
  27. ↑ "Mark Brothers Lectures – Sept. 9, 2003" (PDF). Scope newsletter. Retrieved 9 August 2022.
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