Clitocine
Names
Preferred IUPAC name
(2R,3R,4S,5R)-2-[(6-Amino-5-nitropyrimidin-4-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol
Identifiers
3D model (JSmol)
ChemSpider
  • C1=NC(=C(C(=N1)N[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)[N+](=O)[O-])N
Properties
C9H13N5O6
Molar mass 287.232 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Clitocine is a mushroom nucleoside isolate with anticancer activity in vitro.[1][2][3]

References

  1. ↑ Ren, Gang; Zhao, Yun-Peng; Yang, Lu; Fu, Cheng-Xin (April 2008). "Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis". Cancer Letters. 262 (2): 190–200. doi:10.1016/j.canlet.2007.12.013. PMID 18222036.
  2. ↑ Sun, Jianguo; Yeung, Chilam Au; Co, Ngai Na; Tsang, Tsun Yee; Yau, Esmond; Luo, Kewang; Wu, Ping; Wa, Judy Chan Yuet; Fung, Kwok-Pui; Kwok, Tim-Tak; Liu, Feiyan (2012). "Clitocine reversal of P-glycoprotein associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line". PLOS ONE. 7 (8): e40720. Bibcode:2012PLoSO...740720S. doi:10.1371/journal.pone.0040720. PMC 3425549. PMID 22927901.
  3. ↑ Sun, Jian-guo; Li, Hua; Li, Xia; Zeng, Xueli; Wu, Ping; Fung, Kwok-Pui; Liu, Fei-yan (May 2014). "Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo". Apoptosis. 19 (5): 871–82. doi:10.1007/s10495-014-0969-0. PMID 24563182. S2CID 14746593.


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