Clooney is a surname. Notable people with the surname include:
- Amal Clooney (née Alamuddin) (born 1978), Lebanese-British lawyer and wife of George Clooney
- Francis Xavier Clooney (born 1950), American academic and Roman Catholic priest
- George Clooney (born 1961), American actor
- Nick Clooney (born 1934), American TV host and journalist, father of George
- Rosemary Clooney (1928–2002), American singer and actress, aunt of George
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