In biochemistry, the Corey-Pauling rules are a set of three basic statements that govern the secondary nature of proteins, in particular, the CO-NH peptide link. They were originally proposed by Robert Corey and Linus Pauling.[1]

The rules are as follows:

  1. The atoms in a peptide link all lie on the same plane.
  2. The nitrogen, hydrogen, and oxygen atoms in a hydrogen bond are approximately in a straight line.
  3. The carbon-oxygen and nitrogen-hydrogen groups are all involved in bonding.

References

  1. ↑ John Daintith, ed. (2008). A Dictionary of Chemistry (6th ed.). Oxford University Press. ISBN 9780199204632.


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