DCHS2
Identifiers
AliasesDCHS2, CDH27, CDHJ, CDHR7, PCDH23, PCDHJ, dachsous cadherin-related 2
External IDsOMIM: 612486 HomoloGene: 130686 GeneCards: DCHS2
Orthologs
SpeciesHumanMouse
Entrez

54798

n/a

Ensembl

ENSG00000197410
ENSG00000284227

n/a

UniProt

Q6V1P9

n/a

RefSeq (mRNA)

NM_001142552
NM_001142553
NM_017639
NM_199348
NM_001358235

n/a

RefSeq (protein)

NP_001136024
NP_001345164

n/a

Location (UCSC)Chr 4: 154.23 – 154.49 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Protein dachsous homolog 2, also known as protocadherin-23 (PCDH23) or cadherin-27 (CDH27), is a protein that in humans is encoded by the DCHS2 gene.[3][4]

DCHS2 has been implicated in the nose angle (how much a nose is upturned).[5] As well as facial genetics [6][7]

References

  1. 1 2 3 ENSG00000284227 GRCh38: Ensembl release 89: ENSG00000197410, ENSG00000284227 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: dachsous 2 (Drosophila)".
  4. Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol. 337 (2): 307–17. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.
  5. Adhikari, Kaustubh; et al. (2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications. 7: 11616. Bibcode:2016NatCo...711616A. doi:10.1038/ncomms11616. PMC 4874031. PMID 27193062.
  6. "Facial Genetics: a Brief Overview" (PDF).
  7. "Your nose--Big or small--is shaped by your DNA". Newsweek. 19 May 2016.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.