DGKA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDGKA, DAGK, DAGK1, DGK-alpha, diacylglycerol kinase alpha
External IDsOMIM: 125855 MGI: 102952 HomoloGene: 1028 GeneCards: DGKA
Orthologs
SpeciesHumanMouse
Entrez

1606

13139

Ensembl

ENSG00000065357

ENSMUSG00000025357

UniProt

P23743

O88673

RefSeq (mRNA)

NM_016811
NM_001358745
NM_001358746
NM_001372366
NM_001374028

RefSeq (protein)

NP_058091
NP_001345674
NP_001345675
NP_001359295
NP_001360957

Location (UCSC)Chr 12: 55.93 – 55.95 MbChr 10: 128.56 – 128.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene.[5][6][7]

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000065357 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025357 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hart TC, Champagne C, Zhou J, Van Dyke TE (Jun 1994). "Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12". Mamm Genome. 5 (2): 123–4. doi:10.1007/BF00292343. PMID 8180475. S2CID 305119.
  6. Hart TC, Zhou J, Champagne C, Van Dyke TE, Rao PN, Pettenati MJ (Dec 1994). "Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis". Genomics. 22 (1): 246–7. doi:10.1006/geno.1994.1376. PMID 7959783.
  7. 1 2 "Entrez Gene: DGKA diacylglycerol kinase, alpha 80kDa".

Further reading

[1]*Topham MK, Prescott SM (1999). "Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions". J. Biol. Chem. 274 (17): 11447–50. doi:10.1074/jbc.274.17.11447. PMID 10206945.


  1. Kovalenko A, Sanin A, Kosmas K, Zhang L, Wang J, Giannikou K, Probst CK, Hougard TR, Rue RW, Krymskaya VP, Asara JM, Lam HC, Kwiatkowski DJ, Henske EP, Filippakis H (2021). "Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex". Cancer Research. 81 (8): 2086–2100. doi:10.1158/0008-5472.CAN-20-2218. PMC 8137542. PMID 33593821.
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