DGKB
Identifiers
AliasesDGKB, DAGK2, DGK, DGK-BETA, diacylglycerol kinase beta
External IDsOMIM: 604070 MGI: 2442474 HomoloGene: 37875 GeneCards: DGKB
Orthologs
SpeciesHumanMouse
Entrez

1607

217480

Ensembl

ENSG00000136267

ENSMUSG00000036095

UniProt

Q9Y6T7

Q6NS52

RefSeq (mRNA)

NM_004080
NM_145695

NM_178681
NM_001361686
NM_001361688

RefSeq (protein)

NP_848796
NP_001348615
NP_001348617

Location (UCSC)n/aChr 12: 37.87 – 38.68 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.[4][5]

Function

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.[5]

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036095 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Goto K, Kondo H (August 1993). "Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons". Proceedings of the National Academy of Sciences of the United States of America. 90 (16): 7598–602. Bibcode:1993PNAS...90.7598G. doi:10.1073/pnas.90.16.7598. PMC 47189. PMID 7689223.
  5. 1 2 "Entrez Gene: DGKB diacylglycerol kinase, beta 90kDa".

Further reading

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