DHX34

DHX34
Identifiers
Aliases	DHX34, DDX34, HRH1, DEAH-box helicase 34, DExH-box helicase 34
External IDs	OMIM: 615475 MGI: 1918973 HomoloGene: 69171 GeneCards: DHX34
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,382,704 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	15,955,962 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; right uterine tube; ; right lobe of liver; ; anterior pituitary; ; canal of the cervix; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; left uterine tube; ; upper lobe of left lung;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; yolk sac; ; esophagus; ; submandibular gland; ; islet of Langerhans; ; spermatid; ; stomach; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; hydrolase activity; ATP binding; helicase activity; RNA binding; 3'-5' RNA helicase activity;
Cellular component	membrane; cytoplasm;
Biological process	nuclear-transcribed mRNA catabolic process; RNA processing; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
	Sources:Amigo / QuickGO
Orthologs
	9704
	71723
	ENSG00000134815
	ENSMUSG00000006019
	Q14147
	Q9DBV3
	NM_014681; NM_194428
	NM_001285931; NM_001285932; NM_027883
	NP_055496
	NP_001272860; NP_001272861; NP_082159
	Wikidata
View/Edit Human	View/Edit Mouse

DExH-box helicase 34 is a protein that in humans is encoded by the DHX34 gene. ^[5]

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134815 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006019 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: DExH-box helicase 34". Retrieved 2018-03-21.

Longman D, Hug N, Keith M, Anastasaki C, Patton EE, Grimes G, Cáceres JF (September 2013). "DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans". Nucleic Acids Res. 41 (17): 8319–31. doi:10.1093/nar/gkt585. PMC 3783168. PMID 23828042.
Hug N, Cáceres JF (September 2014). "The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex". Cell Rep. 8 (6): 1845–1856. doi:10.1016/j.celrep.2014.08.020. PMC 4534575. PMID 25220460.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134815 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006019 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DExH-box helicase 34". Retrieved 2018-03-21.

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Function

References

Further reading