DTaP-IPV/Hib vaccine
Combination of
DTaP vaccineVaccine
Inactivated poliovirus vaccineVaccine
Hib vaccineVaccine
Clinical data
Trade namesPentacel, Pediacel, Infanrix IPV + Hib, others
AHFS/Drugs.comFDA Professional Drug Information
Routes of
administration		Intramuscular injection
ATC code
Legal status
Legal status
Identifiers
CAS Number

DTaP-IPV/Hib vaccine is a 5-in-1 combination vaccine that protects against diphtheria, tetanus, whooping cough, polio, and Haemophilus influenzae type B.[1][2]

Its generic name is 'diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and haemophilus B conjugate vaccine', and it is also known as DTaP-IPV-Hib.[1]

Uses

DTaP-IPV/Hib vaccine is administered to young children to immunise against diphtheria, tetanus, pertussis, poliomyelitis, and diseases caused by Haemophilus influenzae type B.[1]

Formulations

A branded formulation marketed in the United States is Pentacel, manufactured by Sanofi Pasteur.[3]

Pentacel is known in the UK and Canada as Pediacel.[4][5]

An equivalent vaccine marketed in the UK and Canada by GlaxoSmithKline is Infanrix IPV + Hib.[5] This is a two-part vaccine. The DTaP-IPV component is supplied as a sterile liquid, which is used to reconstitute lyophilized (freeze-dried) Hib vaccine.

Pentaxim is a liquid formulation marketed by Sanofi Pasteur.[6]

Availability

It is only licensed for young children.[7] In the US the FDA have approved the vaccine for children from age 6 weeks up to age 5 years.[1] It was used in the UK until 2017, following which a 6-in-1 vaccine became available containing the additional protection against Hepatitis B.[2]

References

  1. 1 2 3 4 "Diphtheria and Tetanus Toxoids, Acellular Pertussis, Poliovirus and Haemophilus b Conjugate Vaccine". Drugs.com. Retrieved 15 July 2018.
  2. 1 2 "5-in-1 Vaccine (also called Pentavalent Vaccine)". Vaccine Knowledge Project. 3 January 2021. Retrieved 3 July 2018.
  3. ↑ "Pentacel". U.S. Food and Drug Administration(FDA). STN 125145. Retrieved 15 July 2018.
  4. ↑ "Pediacel syringe - Summary of Product Characteristics (SmPC)". Datapharm. 17 April 2019. Archived from the original on 17 October 2019. Retrieved 16 October 2019.
  5. 1 2 "Diphteria Toxoid: Canadian Immunization Guide". Public Health Agency of Canada. December 2014. Archived from the original on 24 September 2019. Retrieved 16 October 2019.
  6. ↑ Plotkin SA, Liese J, Madhi SA, Ortiz E (July 2011). "A DTaP-IPV//PRP~T vaccine (Pentaxim): a review of 16 years' clinical experience". Expert Rev Vaccines. 10 (7): 981–1005. doi:10.1586/erv.11.72. PMID 21749196. S2CID 207224675.
  7. ↑ "Diphtheria toxoid / haemophilus b conjugate (prp-t) vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid (Pentacel) Use During Pregnancy". Drugs.com. Retrieved 2 January 2021.


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