| Dwarfin sma | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-3 | ||||||
| Entrez | 180431 | ||||||
| RefSeq (mRNA) | NM_075760.6 | ||||||
| RefSeq (Prot) | NP_508161.3 | ||||||
| UniProt | Q95QI7 | ||||||
| Other data | |||||||
| Chromosome | X: 0.82 - 0.83 Mb | ||||||
| |||||||
The DAF-3 or Dwarfin sma is a nematode Caenorhabditis elegans gene encoding a Co-SMAD protein of TGF-beta signaling pathway. Without daf-7 signal, DAF-3 combined with transcription factor daf-5 to form a heterodimer and started dauer development. When daf-7 binds to the receptors daf-1/daf-4, the phosphorylated daf-8/daf-14 heterodimer enter to the nucleus to inhibit this transcription.[1]
References
- ↑ Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.
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