David R. Soll
Born (1942-04-02) April 2, 1942
Philadelphia, Pennsylvania, USA
Alma materUniversity of Wisconsin–Madison
OccupationBiologist
Known forMotion analysis of living cells
monoclonal antibody technologies
Candida albicans
Awards
  • Roy J. and Lucille Carver/Emil Witschi Professorship of the Biological Sciences (1989)
  • Lucille K. George Medal (2009)
  • Rhoda Benham Award (2013)
  • Ian Murray Memorial Award from the British Society of Medical Mycology (1988, 2003)
Scientific career
InstitutionsThe University of Iowa
Developmental Studies Hybridoma Bank
WM Keck Dynamic Image Analysis Facility

David R. Soll (born April 29, 1942) is a professor of Biology at the University of Iowa. He is best known for the motion analysis of living cells, the discovery of Candida albicans phenotypic switching and monoclonal antibody technology.

Soll directed the Developmental Studies Hybridoma Bank from 1995 to 2021, and the WM Keck Dynamic Image Analysis Facility from 1985 to 2021.

A fellow of both the American Academy of Microbiology and the American Association for the Advancement of Science since 2006, he has published more than four hundred articles in various fields of biomedicine.[1] A recipient of more than seventy-eight grants and contracts,[2] he has also founded four companies, and is active on several editorial boards for major scientific publications.[3][4]

Background

Soll was born in South Philadelphia, Pennsylvania, and graduated from Central High School for Boys in 1959 with a bachelor of arts degree. He was inducted into the Central High School Hall of Fame in 2018.

A student at the University of Wisconsin from 1960 to 1969, he earned his bachelor of science, master of science and doctor of philosophy degrees there. He then served as a post-doctoral fellow at Brandeis University, where he taught Introductory Biology.

In 1972, he joined the Department of Biology at the University of Iowa as an assistant professor, was promoted to associate professor in 1976 and to full professor in 1982. In 1989, he was awarded the Roy J. and Lucille Carver/Emil Witschi Professorship of the Biological Sciences; he also became a full professor of Dentistry that same year.

In 2005 and 2006, respectively, he was elected as a fellow of the American Association for the Advancement of Science (AAAS) and the American Academy of Microbiology. In 2009, he was awarded the Lucille K. George Medal from the International Society for Human and Animal Mycology, and in 2013, he was awarded the Rhoda Benham Medal from the Medical Mycological Society of the Americas.

Family

Soll was married for thirty years to Michele Morice (1953-2010), and is currently married to Dr. Melinda A. Weinstein. He has three children, Jacob Soll, Samantha Soll and Benjamin Soll.

Career

From 1965 to 1970, Soll worked on the germination of Blastoclandiella emersonii under the mentorship of David Sonneborn and discovered that complex differentiations can be preprogrammed and occur without RNA or protein synthesis.[5]

From 1972 to 1978, he and his colleagues worked on the "accumulation and erasure of morphogenetics information" in Dictyostelium discoideum.[6] In 1979, he formulated the first model and conditional methods to analyze timer pathways in developing systems.[7] From 1977 to 1984, he developed pH-regulated dimorphism and applied it to study the regulation of the bud-hypha transition in Candida albicans.[8]

Between 1985 and 1987, Soll and his colleagues discovered the first high frequency switching system in the pathogenic yeast Candida albicans. In addition to this phenotypic, morphological switching system, he and his co-workers also discovered the epigenetic, phenotypic white-to-opaque switching system.[9][10]

In 1989, Soll and Dr. E. Voss finished and licensed the Dynamic Motion Analyses System (DMS), to Motion Analyses Corporation of Santa Rosa, CA. In 1997, Soll and Voss obtained the patent for DIAS,[11] the next generation of DMS. In 1992, Soll founded the company Solltech, Inc., a computer software and hardware development company to develop and distribute DIAS.[12]

From 1987 to 1995, Soll and his co-workers developed the first DNA fingerprinting probes for studying the population structure of infectious fungi, and in 1995 received a patent for the software DENDRON, which analyzed DNA fingerprints.[13]

In 1995, Soll formed the company Caviforce Technologies to develop a method of using ultrasound for seed germination. From 1995 to 2004, he and his colleagues developed the first 3D Dynamic Image Analysis System (3D-DIAS) for cells and embryos, describing how embryos form and amoeboid cells crawl.[14][15]

Ultrasound Solutions Inc., was then formed in 1999 to develop the technology to use ultrasound in waste management.[16][17]

In 2003, Soll founded the company Solltechnologies Inc., to sell DIAS and Dendron software. Since 2005, he and his colleagues discovered that Candida albicans forms a "pathogenic" biofilm and a "sexual" biofilm, depending on the configuration of the mating type locus and identified the alternative pathways regulating each biofilm.[18]

From 2011 to present, Soll and his colleagues also developed a 4D model for reconstructing and motion analyzing cancer cells and tumorigenesis.

Current Work

Soll continues to publish on 1) the role of mating and switching in the pathogenesis of Candida albicans, 2) cell motility and the cytoskeleton, 3) advanced monoclonal antibody technology and 4) methods for suppressing tumorigenesis in cancer patients using monoclonal antibodies. In 2019, he began adapting the software programs DIAS and DENDRON to study digitized fine art paintings. [19]

References

  1. ↑ "Profile: David R Soll". ResearchGate.
  2. ↑ "RePORT ⟩ RePORTER".
  3. ↑ "Editorial Board". Archived from the original on 2015-02-11.
  4. ↑ "Cytoskeleton". doi:10.1002/(ISSN)1949-3592.
  5. ↑ Soll, D. R.; Sonneborn, D. R. (1971). "Zoospore germination in Blastocladiella emersonii: Cell differentiation without protein synthesis?". Proceedings of the National Academy of Sciences of the United States of America. 68 (2): 459–63. Bibcode:1971PNAS...68..459S. doi:10.1073/pnas.68.2.459. PMC 388960. PMID 5277101.
  6. ↑ Soll, D. R.; Waddell, D. R. (1975). "Morphogenesis in the slime mold Dictyostelium discoideum. 1. The accumulation and erasure of "morphogenetic information"". Developmental Biology. 47 (2): 292–302. doi:10.1016/0012-1606(75)90283-3. PMID 1239391.
  7. ↑ Soll, D. R. (1979). "Timers in developing systems". Science. 203 (4383): 841–9. Bibcode:1979Sci...203..841S. doi:10.1126/science.419408. PMID 419408.
  8. ↑ Soll, D. R.; Mitchell, L. H. (1983). "Filament ring formation in the dimorphic yeast Candida albicans". The Journal of Cell Biology. 96 (2): 486–93. doi:10.1083/jcb.96.2.486. PMC 2112305. PMID 6339518.
  9. ↑ Slutsky B, Staebell M, Anderson J, Risen L, Pfaller M, Soll DR (1987). ""White-opaque transition": a second high-frequency switching system in Candida albicans". J Bacteriol. 169 (1): 189–97. doi:10.1128/jb.169.1.189-197.1987. PMC 211752. PMID 3539914.
  10. ↑ Slutsky, B; Buffo, J; Soll, D. R. (1985). "High-frequency switching of colony morphology in Candida albicans". Science. 230 (4726): 666–9. Bibcode:1985Sci...230..666S. doi:10.1126/science.3901258. PMID 3901258.
  11. ↑ "Dynamic image analysis system".
  12. ↑ Soll, D. R. (1995). The use of computers in understanding how animal cells crawl. Vol. 163. pp. 43–104. doi:10.1016/S0074-7696(08)62209-3. ISBN 9780123645678. PMID 8522423. {{cite book}}: |journal= ignored (help)
  13. ↑ Soll, D. R. (2000). "The ins and outs of DNA fingerprinting the infectious fungi". Clinical Microbiology Reviews. 13 (2): 332–70. doi:10.1128/cmr.13.2.332-370.2000. PMC 100156. PMID 10756003.
  14. ↑ Heid, P. J.; Voss, E; Soll, D. R. (2002). "3D-DIASemb: a computer-assisted system for reconstructing and motion analyzing in 4D every cell and nucleus in a developing embryo". Developmental Biology. 245 (2): 329–347. doi:10.1006/dbio.2002.0631. PMID 11977985.
  15. ↑ Soll, D. R.; Wessels, D; Kuhl, S; Lusche, D. F. (2009). "How a cell crawls and the role of cortical myosin II". Eukaryotic Cell. 8 (9): 1381–96. doi:10.1128/EC.00121-09. PMC 2747829. PMID 19633268.
  16. ↑ "UI biologist receives grant to study acoustic management of swine odor - University News Service - the University of Iowa". Archived from the original on 2015-02-11. Retrieved 2015-02-11.
  17. ↑ "Help Page -- ScienceDaily". Archived from the original on 2015-02-11.
  18. ↑ Daniels, K. J.; Srikantha, T; Lockhart, S. R.; Pujol, C; Soll, D. R. (2006). "Opaque cells signal white cells to form biofilms in Candida albicans". The EMBO Journal. 25 (10): 2240–52. doi:10.1038/sj.emboj.7601099. PMC 1462973. PMID 16628217.
  19. ↑ Weinstein, Melinda; Voss, Edward; Soll, David (2019). "Dendrography and Art History: a computer-assisted analysis of Cézanne's Bathers". Digital Humanities Quarterly. 13 (3).
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