| DNASE2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | DNASE2, DNASE2A, DNL, DNL2, deoxyribonuclease II, lysosomal, deoxyribonuclease 2, lysosomal, AIPCS | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 126350 MGI: 1329019 HomoloGene: 68179 GeneCards: DNASE2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Deoxyribonuclease II, lysosomal is a protein that in humans is encoded by the DNASE2 gene. [4]
Function
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis.
Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000105612 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: Deoxyribonuclease II, lysosomal". Retrieved 2016-09-07.
Further reading
- Chou SF, Chen HL, Lu SC (2002). "Up-regulation of human deoxyribonuclease II gene expression during myelomonocytic differentiation of HL-60 and THP-1 cells". Biochem. Biophys. Res. Commun. 296 (1): 48–53. doi:10.1016/s0006-291x(02)00835-5. PMID 12147225.
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