Ralph Douglas Kenneth Reye (/raɪ/ "rye"; 5 April 1912 – 16 July 1977) was an Australian pathologist.[1][2] In 1958, he discovered a muscular disease that was later named nemaline myopathy.[3] A brain disease he and his colleagues described in 1963 is eponymously known as Reye's syndrome.[4]

Life and career

Reye attended Townsville Grammar School and the University of Sydney, where he completed undergraduate studies in medicine and was awarded a MBBS in 1937. He was later awarded an MD from the University of Sydney in 1945.[2][4] Reye joined the staff of the Royal Alexandra Hospital for Children (RAHC) in 1939 as a pathologist, and remained there for all his working life. In 1965 Reye was elected as a Fellow of the Royal Australasian College of Physicians. On 16 July 1977, Reye died at the age of 65, of a ruptured abdominal aortic aneurysm at Royal North Shore Hospital, 24 hours after he had retired from the RAHC.[2]

Contributions

Nemaline myopathy

In 1958, Reye identified a disease that involved muscular weakness in which the muscle fibres appeared as thick threads or rods.[5] He did not publish his discovery as it was argued that the microscopic observations could be artefacts.[3] Later known as nemaline myopathy, the medical condition was established independently by American researchers P.E. Cohen and G. M. Shy in 1963.[6][7]

Reye syndrome

In 1963, Reye, Graeme Morgan, and Jim Baral reported a kind of brain disease in The Lancet.[8] The disease was later known as Reye syndrome.[2][4]

References

  1. ↑ Alexander, J. M. (1978). "Ralph Douglas Kenneth Reye". Australian Paediatric Journal. 14 (1): 48. ISSN 0004-993X. PMID 356835.
  2. 1 2 3 4 "Reye, Ralph Douglas Kenneth (1912–1977)". Australian Dictionary of Biography. National Centre of Biography, Australian National University. ISSN 1833-7538. Retrieved 13 February 2012.
  3. 1 2 Schnell, C.; Kan, A.; North, K. N. (2000). "'An artefact gone awry': identification of the first case of nemaline myopathy by Dr R.D.K. Reye". Neuromuscular Disorders. 10 (4–5): 307–312. doi:10.1016/s0960-8966(99)00123-6. ISSN 0960-8966. PMID 10838259. S2CID 38543084.
  4. 1 2 3 "Reye, Ralph Douglas Kenneth". University of Sydney. Retrieved 24 August 2012.
  5. ↑ Bornemann, Antje; Goebel, Hans H. (5 April 2006). "Congenital Myopathies". Brain Pathology. 11 (2): 206–217. doi:10.1111/j.1750-3639.2001.tb00393.x. ISSN 1015-6305. PMC 8098536. PMID 11303796.
  6. ↑ "Nemaline Myopathy - NORD (National Organization for Rare Disorders)". NORD (National Organization for Rare Disorders). Retrieved 10 April 2016.
  7. ↑ Brooke, M. H.; Carroll, J. E.; Ringel, S. P. (1979). "Congenital hypotonia revisited". Muscle & Nerve. 2 (2): 84–100. doi:10.1002/mus.880020203. ISSN 0148-639X. PMID 397413. S2CID 29702871.
  8. ↑ Reye, R. D.; Morgan, G.; Baral, J. (1963). "Encephalopathy and Fatty Degeneration of the Viscera: A Disease Entity in Childhood". Lancet. 2 (7311): 749–752. doi:10.1016/s0140-6736(63)90554-3. ISSN 0140-6736. PMID 14055046.
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