Dual specificity phosphatase 8

DUSP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JMK
Identifiers
Aliases	DUSP8, C11orf81, HB5, HVH-5, HVH8, dual specificity phosphatase 8
External IDs	OMIM: 602038 MGI: 106626 HomoloGene: 31239 GeneCards: DUSP8
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,572,271 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,649,580 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; superior frontal gyrus; ; prefrontal cortex; ; nucleus accumbens; ; putamen; ; temporal lobe; ; amygdala; ; hippocampus proper; ; dorsolateral prefrontal cortex; ; caudate nucleus;
	Top expressed in
	subiculum; ; Region I of hippocampus proper; ; superior frontal gyrus; ; olfactory tubercle; ; dorsal tegmental nucleus; ; nucleus accumbens; ; cerebellar cortex; ; medial geniculate nucleus; ; cerebellar vermis; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; phosphatase activity; protein tyrosine phosphatase activity;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	protein dephosphorylation; dephosphorylation; peptidyl-tyrosine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	1850
	18218
	ENSG00000184545; ENSG00000273793; ENSG00000278165
	ENSMUSG00000037887
	Q13202
	O09112
	NM_004420
	NM_008748
	NP_004411
	NP_032774
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity phosphatase 8 is a protein that in humans is encoded by the DUSP8 gene. ^[5]

Function

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

References

1 2 3 ENSG00000273793, ENSG00000278165 GRCh38: Ensembl release 89: ENSG00000184545, ENSG00000273793, ENSG00000278165 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037887 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Dual specificity phosphatase 8". Retrieved 2017-09-08.

Function

References

Further reading