EDEM3

EDEM3
Identifiers
Aliases	EDEM3, C1orf22, ER degradation enhancing alpha-mannosidase like protein 3, CDG2V
External IDs	OMIM: 610214 MGI: 1914217 HomoloGene: 11866 GeneCards: EDEM3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	184,754,907 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	151,697,802 bp
RNA expression pattern
	Top expressed in
	pylorus; ; jejunal mucosa; ; spongy bone; ; islet of Langerhans; ; stromal cell of endometrium; ; cardia; ; body of pancreas; ; rectum; ; bronchial epithelial cell; ; lower lobe of lung;
	Top expressed in
	lacrimal gland; ; seminal vesicula; ; salivary gland; ; parotid gland; ; submandibular gland; ; cumulus cell; ; left lung lobe; ; pineal gland; ; epithelium of stomach; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; hydrolase activity; metal ion binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; catalytic activity;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; membrane; endoplasmic reticulum quality control compartment;
Biological process	endoplasmic reticulum unfolded protein response; protein glycosylation; N-glycan processing; response to unfolded protein; glycoprotein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; mannose trimming involved in glycoprotein ERAD pathway;
	Sources:Amigo / QuickGO
Orthologs
	80267
	66967
	ENSG00000116406
	ENSMUSG00000043019
	Q9BZQ6
	Q2HXL6
	NM_025191; NM_001319960
	NM_001039644; NM_001311165; NM_001311166
	NP_001306889; NP_079467
	NP_001034733; NP_001298094; NP_001298095
	Wikidata
View/Edit Human	View/Edit Mouse

ER degradation-enhancing alpha-mannosidase-like 3 is an enzyme that in humans is encoded by the EDEM3 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116406 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043019 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
↑ Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
↑ "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Hirao K, Natsuka Y, Tamura T, et al. (2006). "EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming". J. Biol. Chem. 281 (14): 9650–8. doi:10.1074/jbc.M512191200. PMID 16431915.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116406 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043019 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15537790-5] Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.

[pmid15579471-6] Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.

[entrez-7] "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3".

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References

Further reading