ENC1
Identifiers
AliasesENC1, CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10, ectodermal-neural cortex 1
External IDsOMIM: 605173 MGI: 109610 HomoloGene: 2694 GeneCards: ENC1
Orthologs
SpeciesHumanMouse
Entrez

8507

13803

Ensembl

ENSG00000171617

ENSMUSG00000041773

UniProt

O14682

O35709

RefSeq (mRNA)

NM_001256574
NM_001256575
NM_001256576
NM_003633

NM_007930

RefSeq (protein)

NP_001243503
NP_001243504
NP_001243505
NP_003624

NP_031956

Location (UCSC)Chr 5: 74.63 – 74.64 MbChr 13: 97.24 – 97.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene.[5][6][7]

Function

DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM][7]

Interactions

ENC1 has been shown to interact with Retinoblastoma protein.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171617 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041773 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. Bibcode:1997Natur.389..300P. doi:10.1038/38525. PMID 9305847. S2CID 4429638.
  6. 1 2 Kim TA, Lim J, Ota S, Raja S, Rogers R, Rivnay B, Avraham H, Avraham S (May 1998). "NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation". The Journal of Cell Biology. 141 (3): 553–66. doi:10.1083/jcb.141.3.553. PMC 2132755. PMID 9566959.
  7. 1 2 "Entrez Gene: ENC1 ectodermal-neural cortex (with BTB-like domain)".

Further reading

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