| Sterol C-5 desaturase | |
|---|---|
| Identifiers | |
| Organism | |
| Symbol | ERG3 |
| Alt. symbols | SC5D, SYR1 |
| Entrez | 850745 |
| HomoloGene | 5044 |
| RefSeq (mRNA) | NM_001181943 |
| Other data | |
| EC number | 1.14.19.20 |
| Chromosome | XII: 0.25 - 0.25 Mb |
ERG3 or sterol C-5 desaturase is a fungal enzyme originally from Saccharomyces cerevisiae, the human ortholog of ERG3 is SC5D.[1] ERG3 localizes to both the endoplasmic reticulum and vesicles,[2][3] catalyzes the C5(6)-dehydrogenation of episterol to 5-dehydroepisterol, 5-Dehydroepisterol will be further converted into ergosterol.[4][5]
The precise structural details of C-5 sterol desaturase substrates vary across eukaryotes. Shown below the reaction scheme are three possible distal groups along with biosynthetic pathways and species they are found in.[6]
See also
References
- ↑ Hemmi K, Julmanop C, Hirata D, Tsuchiya E, Takemoto JY, Miyakawa T (March 1995). "The physiological roles of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae". Bioscience, Biotechnology, and Biochemistry. 59 (3): 482–6. doi:10.1271/BBB.59.482. PMID 7766188.
- ↑ Natter K, Leitner P, Faschinger A, Wolinski H, McCraith S, Fields S, Kohlwein SD (May 2005). "The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy". Molecular & Cellular Proteomics. 4 (5): 662–72. doi:10.1074/mcp.M400123-MCP200. PMID 15716577.
- ↑ Poklepovich TJ, Rinaldi MA, Tomazic ML, Favale NO, Turkewitz AP, Nudel CB, Nusblat AD (November 2012). "The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae". Steroids. 77 (13): 1313–20. doi:10.1016/j.steroids.2012.08.015. PMC 3501532. PMID 22982564.
- ↑ Brumfield KM, Moroney JV, Moore TS, Simms TA, Donze D (January 2010). "Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol". PLOS ONE. 5 (1): e8659. Bibcode:2010PLoSO...5.8659B. doi:10.1371/journal.pone.0008659. PMC 2799552. PMID 20084111.
- ↑ Miyazaki T, Miyazaki Y, Izumikawa K, Kakeya H, Miyakoshi S, Bennett JE, Kohno S (February 2006). "Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance". Antimicrobial Agents and Chemotherapy. 50 (2): 580–6. doi:10.1128/AAC.50.2.580-586.2006. PMC 1366932. PMID 16436713.
- ↑ Choe S, Noguchi T, Fujioka S, Takatsuto S, Tissier CP, Gregory BD, et al. (February 1999). "The Arabidopsis dwf7/ste1 mutant is defective in the delta7 sterol C-5 desaturation step leading to brassinosteroid biosynthesis". The Plant Cell. 11 (2): 207–21. doi:10.1105/tpc.11.2.207. PMC 144158. PMID 9927639.
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