North America Relegation

North America's league featured an unusual case. Immortals decided to drop out of EPL after Vito "kNgV-" Giuseppe's contract was cut and Henrique "HEN1" Teles and Lucas "LUCAS1" Teles's contracts were bought out by 100 Thieves along with Lincoln "fnx" Lau. Immortals tried to rebuild its team with its last two members in Lucas "steel" Lopes and Ricardo "boltz" Prass by bringing in João "horvy" Horvath, Lucas "destinyy" Bullo, and Caio "zqk" Fonseca. However, boltz was later loaned to SK Gaming and was projected to become part of the permanent roster, so the team brought in Bruno "shz" Martinelli. However, Team Liquid bought out steel, horvy announced that he would go inactive in search of a better team, and destinyy and shz went back to their old team Tempo Storm. zqk then left the team to join the Brazilian-based YeaH! Gaming. 100 Thieves potentially could have bought Immortals's Pro League license, but the CS:GO project fell through as unspecified members were having immigration issues and then 100 Thieves released its CS:GO squad and then the team announced it would not reach out to any CS:GO team for 2018. Therefore, Ghost Gaming, which was going to be relegated to the Premier League, got a second chance to get back into Pro League by taking Immortals's spot in the Season 6 relegation phase.

Europe Relegation

Australia-New Zealand

The Australia-New Zealand (ANZ) season matches will take place from April 4 to 5 and April 9 to 10. The top three will qualify for the APAC finals.

China

The China region consists of the East Asia countries. The China season will take place from March 27 to 29. The top three will qualify for the APAC finals.

Southeast Asia

The Southeast Asia season matches will take place from April 6 to 8. The top two will advance to the APAC finals.

Group A

mousesports was the top feature in Group A after winning the Europe division and the team was in its strongest form ever in team history, winning StarLadder & i-League StarSeries Season 4 and upsetting FaZe Clan in the V4 Future Sports Festival in another tournament win. In addition, it came in a solid third-place finish at the Intel Extreme Masters Season XIII – Sydney. NRG Esports was also in its strongest form as it topped the Esports Championship Series Season 5 North America division; however, NRG finished in a very disappointing 9th place at IEM Sydney in its only premier LAN tournament. Natus Vincere quickly turned things around lead by Oleksandr "s1mple" Kostyliev dominating performances, leading to two runner-up finishes at StarLadder Season 4 and at DreamHack Masters Marseille 2018 after Na'Vi had struggled for the most part of 2017. FaZe Clan was also in the group as after falling short at five straight tournaments, the team finally won IEM Sydney in a sweep, but close series, against Astralis. The defending major champions Cloud9 had a disappointing path after the major after the departure of Jake "Stewie2K" Yip, finishing 9th at StarLadder Season 4 and fifth at three straight LANs, two of which ended up being upsets against the team. HellRaisers managed to sneak into another finals and looked to replicate its playoff run from last season. HellRaisers won the Bets.net Masters: Season 1 over North and a solid third place at the V4 festival, but had no other results to show for. MVP PK was quickly improving in the Asian region under the leadership of legendary 1.6 player Kang "solo" Keun-chul. The Koreans placed 9th at IEM Sydney 2018, but was eliminated by mousesports and had a close map against the Europeans. Its most impressive run was at World Electronic Sports Games 2017, where it split two maps with Team Russia and went to the playoffs over Team EnVyUs and had an extremely close first map against Fnatic in the quarterfinals. Sharks Esports was the weakest team in the finals, but the team managed to pull off two major upsets in the LA League over Isurus Gaming and Furia eSports. mousesports, FaZe Clan, and Natus Vincere were the favorites to move on to the playoffs.

Group B

Team Liquid headlined group B by topping the North American division and after a successful run of tournaments, the sudden departure of Lucas "steel" Lopes due to personal issues had the team acquire Epitactio "TACO" de Melo, who had just left SK Gaming. After acquiring TACO, the team failed to qualify for IEM Sydney 2018 and finished in a rough 9th place at Intel Extreme Masters Season XII – World Championship Astralis was also in the group as the current world number one won DreamHack Masters Marseille 2018 and was the runner-up at IEM Sydney. Ninjas in Pyjamas was in the group after finishing second in Europe, but its recent tournaments only showed mediocre results, losing to the inconsistent Heroic, Team Liquid, Fnatic, and the struggling Virtus.pro in a qualifier to IEM Sydney. Renegades exceeded many expectations in 2018 after making the playoffs at StarLadder Season 4 and nearly knocking off mousesports in front of its home crowd at IEM Sydney. Space Soldiers surprised Europe after being in first place for a long time and ended up in fourth to qualify for the playoffs. However, other than a WESG 2017 runner-up performance, Space Soldiers didn't have any other results to prove that it could compete with the best. OpTic Gaming was the biggest question mark coming into the tournament as Shahzeeb "ShahZaM" Khan and Peter "stanislaw" Jarguz left the team and OpTic made the team fully Danish. In 2018, OpTic had zero LAN results as it fell at every online qualifier. SK Gaming was once the most dominating force, but 2018 was a massive struggle for it and appeared even worse after TACO left the team and Stewie2K joined. After a strong major performance at third place, the team suffered upset after upset, losing to Team Liquid twice, Cloud9 at IEM Worlds, losing to BIG and Team Russia to finish in 17th at WESG 2017, struggled against mousesports at DreamHack Masters Marseille 2018, and was upset by TyLoo and Grayhound Gaming at IEM Sydney, which was the tournament the Brazilians had won the year before. SK looked to defend its EPL title after barely sneaking into the season 7 finals. Grayhound rounded up the list. The team finished in second at the CS:GO Asia Summit to MVP PK and upset SK Gaming at IEM Sydney and fell to the eventual champions FaZe Clan. Aside from Astralis, there was no clear favorite to go through to the playoffs.

Quarterfinals

Team Liquid had a relatively easy time in the group stage until Astralis's Nicolai "dev1ce" Reedtz put up a masterclass performance to completely shut down Liquid. The number one overall seeded mousesports had a tough time in the group stage after winning a closer than expected game against Sharks, being thrashed by FaZe Clan, and pulling off two wins in the loser's bracket that might have gone either way. Historically, mousesports's roster has a slight 7–5 map record over Liquid. In the other quarterfinals matchup, the FaZe Clan-SK Gaming rivalry continued. FaZe's captain Finn "karrigan" Andersen had never won a series against SK's captain Gabriel "FalleN" Toledo, but with SK only testing new waters and having communication issues as it brought in the American Jake "Stewie2K" Yip, this was karrigan's chance to finally get a series win over FalleN. FalleN had a 9–0 series lead over karrigan and a 10–0 record on Overpass against the Danish in-game leader.

The first game of the playoffs started off on Mirage, mousesports's pick and best map and the map proved to be a thriller. mousesports looked to take the map late in the game, but and resurgence from Liquid allowed the Americans to get map point first. However, mousesports was able to tie it after thirty rounds to send the game to overtime. Liquid started the overtime strong by taking two of three rounds in the first overtime half and then got to match point, but the resilience of the Europeans pushed the game to a second overtime. The first five rounds went exactly as the first overtime and the game looked to go to a triple overtime. However, Liquid was able to pull through to steal the map away. Dust II was the next map, a map that mousesports was famed for when Nikola "NiKo" Kovač was on the team before transferring to FaZe. However, Liquid rode the wave of momentum and had a dominant first half. Liquid went up 14–4 after winning the pistol round and the two follow-up rounds. Liquid was able to clean up the overall number one seeded team and moved on to the semifinals against Natus Vincere.

FaZe Clan started extremely strong on Overpass against SK Gaming with a 7–0 lead, which included a 1 vs. 4 clutch from karrigan, but SK was able to bring the score within two before FaZe took the last three rounds. FaZe later went up to 13–5, which looked to be the end of SK. However, SK paced itself back into the match and the score later reached a 15–13 scoreline. However, a desert eagle shot from NiKo to take out Stewie2K gave FaZe enough room to take over the A bombsite and eventually Håvard "rain" Nygaard won the duel against Marcelo "coldzera" David in the battle of two top five players as karrigan finally defeated FalleN on Overpass for the first time in his career. FaZe would later expose SK's flaws as it dominated the first half. FaZe booked a ticket to a match with Astralis as karrigan finally had his first series win against FalleN, albeit not with FalleN in-game leading as coldzera had recently taken over the role and the defending champions were knocked out.

Semifinals

Fresh off of its win over mousesports, Liquid looked to move on to another grand finals. On the other hand, Natus Vincere was in its best form ever since picking up Oleksandr "s1mple" Kostyliev from Team Liquid. s1mple's current team was the favored team in the matchup against his former team. Meanwhile, a rematch of IEM Sydney 2018 took place in the second semifinals, in which FaZe won one of the closest 3–0 over Astralis. FaZe was coming off of its high by beating SK Gaming for the first time ever.

Na'Vi jumped out to a massive 8–3 lead before Liquid started to recover by winning three of the last four rounds to keep the score relatively close. Na'Vi later made it 12–6, but Liquid took over from there. Lead by newly acquired Epitácio "TACO" de Melo's entry fragging, the American team took nine of the next ten rounds to reach map point first. Na'Vi won the twenty-ninth round to potentially send the game to overtime, but Liquid denied it and took the first map in regulation. Liquid continued its hot streak by going up 8–0 on Inferno, the second map, before Na'Vi struggled to pull away four rounds in the first half. Na'Vi did better the second half, but could not recover from the damage Liquid inflicted in the first and Liquid moved on to another grand finals.

The second semifinals was supposed to be a potential grand finals matchup, but the series proved to be underwhelming. On the first map, Astralis had a slight 3–2 edge. However, the Danes never looked back after that and jumped to a 12–3 halftime lead. The second half was a simple cleanup of the job they had to easily take the first map. The second map was even more one-sided as Astralis took a 9–0 lead and finished the half with a 13–2 lead. FaZe took four rounds in the second half, but the game was too far out of reach and Astralis moved on to another final.

Grand finals

Both teams looked to win their first EPL title. Liquid's best performance was at the Season 5 Finals, where it placed third, and Astralis's best placement was at the Season 2 Finals, where it placed third when it was playing under the ? banner. With Astralis breezing past the second best team in the world, the Danes were heavily favored to win the series, but Liquid was playing in front of its home crowd.

Astralis came out the door swinging and easily took the first game, allowing just one round to Liquid and made the Americans look worse than FaZe. However, in the second map, Liquid made it close after the first half, taking six rounds. Liquid looked to solve the Astralis puzzle as it was within a couple rounds to win the second game, but Astralis turned its gears on to just about come back on Nuke to take a stranglehold on the series, but Liquid did prove that it could hang with the best. Mirage proved to be another thriller as it went to another thirtieth round and Liquid was down 13–7. Astralis had a 4 vs. 3 advantage and wanted to plant the bomb, but Keith "NAF" Markovic pushed at just the right time and four Astralis members went down and Liquid was the first team at the event to take a map off of Astralis. Liquid looked to be getting stronger as the series went on as the North American team reached ten rounds in the first half on the fourth map. Liquid looked to pull away, but Astralis started a comeback in the second half, where the top Danish team was known for its counter-terrorist side and tied it at 11. Astralis would pull away by shutting down the offense of Liquid to take home its first EPL title.