Edmund Carl Kornfeld
Born(1919-02-24)February 24, 1919
Philadelphia, Pennsylvania, US
DiedJune 22, 2012(2012-06-22) (aged 93)
EducationTemple University (AB)
Harvard University (PhD)

Edmund Carl Kornfeld (24 February 1919 – 22 June 2012) was an American organic chemist who devoted his life to the research of new drugs.[1] His leading discovery, with the help of a team, was an antibiotic that was later named vancomycin.[2][3]

Early life and education

Edmund Carl Kornfeld was born on February 24, 1919, in Philadelphia, Pennsylvania, to Elsie and Julius Kornfeld. He received his AB from Temple University in 1940 and his PhD in chemistry from Harvard University in 1944.[4]

Career

In 1946, he joined Eli Lilly and Company in Indianapolis, Indiana, where most of his discoveries took place.[4] In 1953, Kornfeld and his team discovered a microbe, Streptomyces orientalis, which was found in soil samples from Borneo. Later that year, they discovered that this microbe produced a unique compound that had the remarkable property of killing all staphylococcal bacteria, including the penicillin-resistant strains. The drug’s ability to inhibit staphylococci was stable during early assays, suggesting that it might be clinically useful for a long period.[3]

One of the most difficult tasks that Kornfeld and his team faced was purifying the new compound. The purification method employed during that time utilized picric acid - a potentially explosive chemical; because of this, an alternate process was developed. However, this new method yielded material with a purity of only 82% and, when solubilized, produced a brown liquid aptly termed "Mississippi mud". However, due to the need for an alternative to penicillin for resistant bacterial infections, the initial preparations were considered safe enough for use in humans.[3]

The drug was given to a patient who had developed a severe infection on his foot after surgery which had been unresponsive to multiple antibiotics. The surgical staff had recommended amputation or the use of the new antibiotic. His answer was, "Anything that might save my foot". Due to the spread of the bacteria, a high dosage of the antibiotic 05865 was recommended, 100 mg every eight hours, over five days. After the first day, the heat was decreasing, his white cell count was dropping, and the exudate of his wound was less. During the next seven days, the staphylococci disappeared from the wound, and his foot was free from any sign of infection. Two months later, he left the hospital with an intact foot.[3]

The new antibiotic was named vancomycin, from the term "vanquish," and was approved by the U.S. Food and Drug Administration in 1958.[3]

In 1956, with help from Robert Burns Woodward, Kornfeld was successful in synthesizing the first lab-produced lysergic acid (LSD).[5] Eli Lilly was looking for a treatment for anxiety, depression, psychosomatic diseases, and addiction.

Kornfeld's research also resulted in the discovery of pergolide as a medication for Parkinson's disease.[6]

Published books

Condensation of heterocyclic bases with acetylene dicarboxylic ester. Publisher: Harvard University, 1945.

The Total Synthesis of Lysergic Acid.[5] Edmund C. Kornfeld, E. J. Fornefeld, G. Bruce Kline, Marjorie J. Mann, Dwight E. Morrison, Reuben G. Jones, R. B. Woodward.

References

  1. ↑ "Edmund C. Kornfeld Obituary: View Edmund Kornfeld's Obituary by The Indianapolis Star". Legacy.com. 2012-06-22. Retrieved 2012-07-06.
  2. ↑ Griffith RS. Introduction to vancomycin. Rev Infect Dis 1981;3:S200-4
  3. 1 2 3 4 5 Esposito, Anthony (July–August 2011). "That Which Endures: The Quiet Heroes of Medical Discovery" (PDF). Worcester Medicine. 75 (4): 9–13. Retrieved 1 October 2023.
  4. 1 2 Monsma, John Clover, ed. (1958). The Evidence of God in an Expanding Universe: Forty American Scientists Declare their Affirmative Views on Religion. New York: G.P. Putnam's Sons. p. 174. A.B., Temple University, M.A., Ph.D., Harvard University. Since 1946 with the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis; presently Head of Organic Chemical Division. Specialist in rubber chemistry, synthetic organic medicinals, organic chemicals development.
  5. 1 2 Edmund C. Kornfeld, E.J. Fornefeld, G. Bruce Kline, Marjorie J. Mann, Dwight E. Morrison, Reuben G. Jones and R.B. Woodward (1956). "The Total Synthesis of Lysergic Acid". Journal of the American Chemical Society 78: 3087-3114.
  6. ↑ US patent 4166182A, Edmund C. Kornfeld & Nicholas J. Bach, "6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds", published 1979-08-28, issued 1979-08-28, assigned to Eli Lilly and Co
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