Eleftheria Maratos-Flier is an American endocrinologist,[1] and emerita Professor of Medicine at Harvard Medical School,[2] best known for her expertise in the pathophysiology and prevention of obesity-related metabolic disorders,[3][4] and for her discoveries on the neuroendocrine control of feeding behaviour.[5][6] She is a contributing author to known textbooks and reviews in internal medicine,[7] endocrinology,[8] and physiology.[9] Her marriage with professor Jeffrey Flier, was noted by Forbes[10] as a lasting and productive bond between eminent medical scholars.[11] They have two adult daughters who are also physicians. She is also known as Terry Maratos-Flier.[12]

Education

In 1972, she graduated with a BA in Chemistry from New York University, New York, NY.[13] In 1976, she graduated as an MD from the Mount Sinai School of Medicine, New York, NY,[14] followed by internship and residency training in internal medicine at George Washington University Hospital, Washington, DC.[15] In Massachusetts (1978-1981), she pursued further residency training in internal medicine at Beth Israel Hospital, postdoctoral research fellowship at Harvard School of Public Health, and Clinical Fellowship at the Joslin Diabetes Center and Brigham and Women’s Hospital.[2][15]

Career

Since 1982 she has taught at Harvard Medical School, becoming a full Professor of Medicine from 2010 to 2018, when she became professor emerita.[16] She has been an associate member of the Broad Institute,[17] and a Principal Investigator of many NIH-funded research grants.[18] She has also been an attending endocrinologist at Beth Israel Deaconess Medical Center, where she still provides care for patients with metabolic disease.[19] From 2018, she has been Director, Translational Medicine, at Novartis Institutes of Biomedical Research, Cambridge, MA.,[20] recently moving to Alnylam to serve as a director of clinical research. She has authored more than 100 peer-reviewed papers,[21] most of them studying aspects of obesity and type II diabetes in experimental mouse models, and also in clinical disease. She also authored the obesity chapters of the 20th edition of Harrison's Principles of Internal Medicine (jointly with Jeffrey Flier),[7] and the 14th edition of Williams Textbook of Endocrinology.[8] In 2016, she contributed an article to the Annual Review of Physiology on the physiology of Fibroblast Growth Factor 21.[9]

Awards

  • 1971 - Undergraduate Award in Analytical Chemistry from the ACS to outstanding undergraduate chemistry students.[13]
  • 2011 - Saul Horowitz Distinguished Alumni Award, given for outstanding achievements since graduation from the Icahn School of Medicine at Mount Sinai.[14]
  • 2020 - Roy O. Greep Award for Outstanding Research given by the Endocrine Society.[22]

Selected works

Maratos-Flier's research papers have been cited over 15,600 times.[21] Her most cited papers are:

  • Qu, Daqing; Ludwig, David S.; Gammeltoft, Steen; Piper, Megan; Pelleymounter, Mary Ann; Cullen, Mary Jane; Mathes, Wendy Foulds; Przypek, Jeanne; Kanarek, Robin; Maratos-Flier, Eleftheria (1996-03-01). "A role for melanin-concentrating hormone in the central regulation of feeding behaviour". Nature. 380 (6571): 243–247. doi:10.1038/380243a0.PMID 8637571.[6]
  • Ahima, Rexford S.; Prabakaran, Daniel; Mantzoros, Christos; Qu, Daqing; Lowell, Bradford; Maratos-Flier, Eleftheria; Flier, Jeffrey S. (1996-07-01). "Role of leptin in the neuroendocrine response to fasting". Nature. 382 (6588): 250–252. doi:10.1038/382250a0. PMID 8717038.[5]
  • Badman, Michael K.; Pissios, Pavlos; Kennedy, Adam R.; Koukos, George; Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2007-06-01). "Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States". Cell Metabolism. 5 (6): 426–437. doi:10.1016/j.cmet.2007.05.002. PMID 17550778.[23]
  • Fisher, ffolliott M.; Kleiner, Sandra; Douris, Nicholas; Fox, Elliott C.; Mepani, Rina J.; Verdeguer, Francisco; Wu, Jun; Kharitonenkov, Alexei; Flier, Jeffrey S.; Maratos-Flier, Eleftheria; Spiegelman, Bruce M. (2012-02-01). "FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". Genes & Development. 26 (3): 271–281. doi:10.1101/gad.177857.111. PMID 22302939[24]

References

  1. ↑ "Meet the 2020 Laureates: Eleftheria Maratos-Flier, MD". Endocrine News. 2020-03-05. Retrieved 2022-03-19.
  2. 1 2 "SSIB 2017 MARS Speakers". www.ssib.org. Retrieved 2022-03-19.
  3. ↑ Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2007). "What Fuels Fat". Scientific American. 297 (3): 72–81. Bibcode:2007SciAm.297c..72F. doi:10.1038/scientificamerican0907-72. PMID 17784627. Retrieved 2022-03-18.
  4. ↑ "Can't resist candy? You may have this mutation". PBS NewsHour. 2017-05-08. Retrieved 2022-03-18.
  5. 1 2 Ahima, Rexford S.; Prabakaran, Daniel; Mantzoros, Christos; Qu, Daqing; Lowell, Bradford; Maratos-Flier, Eleftheria; Flier, Jeffrey S. (1996-07-01). "Role of leptin in the neuroendocrine response to fasting". Nature. 382 (6588): 250–252. Bibcode:1996Natur.382..250A. doi:10.1038/382250a0. ISSN 0028-0836. PMID 8717038. S2CID 4331304.
  6. 1 2 Qu, Daqing; Ludwig, David S.; Gammeltoft, Steen; Piper, Megan; Pelleymounter, Mary Ann; Cullen, Mary Jane; Mathes, Wendy Foulds; Przypek, Jeanne; Kanarek, Robin; Maratos-Flier, Eleftheria (1996-03-01). "A role for melanin-concentrating hormone in the central regulation of feeding behaviour". Nature. 380 (6571): 243–247. Bibcode:1996Natur.380..243Q. doi:10.1038/380243a0. ISSN 0028-0836. PMID 8637571. S2CID 42701304.
  7. 1 2 Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2018). Harrison's principles of internal medicine. Chapter 394: Pathobiology of Obesity (20th ed.). New York: McGraw Hill. ISBN 978-1-259-64403-0. OCLC 1029074059.
  8. 1 2 Maratos-Flier, Elephteria (2020). Obesity chapter in Williams textbook of endocrinology. Shlomo Melmed, Richard J. Auchus, Allison B. Goldfine, Ronald Koenig, Clifford J. Rosen, Robert Hardin Preceded by: Williams (14 ed.). Philadelphia, PA: Saunders. pp. 1567–1580, Obesity chapter. ISBN 978-0323555968. OCLC 1131863622.
  9. 1 2 Fisher, Ffolliott Martin; Maratos-Flier, Eleftheria (2016). "Understanding the Physiology of FGF21". Annual Review of Physiology. 78: 223–241. doi:10.1146/annurev-physiol-021115-105339. ISSN 1545-1585. PMID 26654352.
  10. ↑ Shaywitz, David. "Power couples: common in medicine, rare in business?". Forbes. Retrieved 2022-03-02.
  11. ↑ Flier, Jeffrey S. (2012-09-01). "Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21". The Yale Journal of Biology and Medicine. 85 (3): 405–414. ISSN 1551-4056. PMC 3447204. PMID 23012588.
  12. ↑ "ORCID". orcid.org. Retrieved 2022-03-02.
  13. 1 2 "American Chemical Society Award Winners, Washington, D.C." Analytical Chemistry. 43 (12): 63A–73A. 1971-10-01. doi:10.1021/ac60306a706. ISSN 0003-2700.
  14. 1 2 "Alumni Award Recipients". alumni.icahn.mssm.edu. Retrieved 2022-03-19.
  15. 1 2 "Eleftheria Maratos-Flier, MD".
  16. ↑ "New Appointments to Full Professor (12/22/10)". hms.harvard.edu. Retrieved 2022-03-19.
  17. ↑ "Team". Broad Institute. 2008-04-23. Retrieved 2022-03-19.
  18. ↑ "Eleftheria Maratos-Flier". grantome.com.
  19. ↑ "Meet Our Endocrinology, Diabetes and Metabolism Experts". www.bidmc.org. Retrieved 2022-03-19.
  20. ↑ Rader, Daniel J.; Maratos-Flier, Eleftheria; Nguyen, Amanda; Hom, Doug; Ferriere, Michael; Li, Yifang; Kompa, Jill; Martic, Miljen; Hinder, Markus; Basson, Craig T.; Yowe, David (2022-01-01). "LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia". The Journal of Clinical Endocrinology and Metabolism. 107 (1): e57–e70. doi:10.1210/clinem/dgab624. ISSN 1945-7197. PMC 8914500. PMID 34431493.
  21. 1 2 "Scopus preview - Maratos-Flier, Eleftheria - Author details - Scopus". www.scopus.com. Retrieved 2022-03-19.
  22. ↑ "An Appetite for Research: Q&A with Eleftheria Maratos-Flier, MD". Endocrine News. 2020-10-05. Retrieved 2022-03-02.
  23. ↑ Badman, Michael K.; Pissios, Pavlos; Kennedy, Adam R.; Koukos, George; Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2007-06-01). "Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States". Cell Metabolism. 5 (6): 426–437. doi:10.1016/j.cmet.2007.05.002. PMID 17550778.
  24. ↑ Fisher, ffolliott M.; Kleiner, Sandra; Douris, Nicholas; Fox, Elliott C.; Mepani, Rina J.; Verdeguer, Francisco; Wu, Jun; Kharitonenkov, Alexei; Flier, Jeffrey S.; Maratos-Flier, Eleftheria; Spiegelman, Bruce M. (2012-02-01). "FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". Genes & Development. 26 (3): 271–281. doi:10.1101/gad.177857.111. ISSN 0890-9369. PMC 3278894. PMID 22302939.
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