FAM132A

C1QTNF12
Identifiers
Aliases	C1QTNF12, C1QDC2, CTRP12, FAM132A, family with sequence similarity 132 member A, C1q and TNF related 12
External IDs	OMIM: 616593 MGI: 1914639 HomoloGene: 12123 GeneCards: C1QTNF12
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,246,722 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	156,051,086 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; skin of abdomen; ; gastric mucosa; ; skin of limb; ; right lobe of liver; ; kidney; ; renal cortex; ; left uterine tube; ; stromal cell of endometrium;
	Top expressed in
	medullary collecting duct; ; renal corpuscle; ; condyle; ; fossa; ; retinal pigment epithelium; ; Paneth cell; ; brown adipose tissue; ; external carotid artery; ; lip; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of glucose import; negative regulation of gluconeogenesis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of insulin receptor signaling pathway; positive regulation of protein kinase B signaling; regulation of glucose metabolic process; negative regulation of inflammatory response; regulation of glucose import; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	388581
	67389
	ENSG00000184163
	ENSMUSG00000023571
	Q5T7M4
	Q8R2Z0
	NM_001014980
	NM_026125
	NP_001014980
	NP_080401
	Wikidata
View/Edit Human	View/Edit Mouse

Family with sequence similarity 132, member A also known as adipolin is a protein that in humans is encoded by the FAM132A gene.^[5] Adipolin is an adipokine.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000184163 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023571 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Family with sequence similarity 132, member A".

Wei Z, Lei X, Seldin MM, Wong GW (October 2012). "Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity". J. Biol. Chem. 287 (43): 35804–14. doi:10.1074/jbc.M112.365965. PMC 3476250. PMID 22942287.
Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N (October 2011). "Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism". J. Biol. Chem. 286 (40): 34552–8. doi:10.1074/jbc.M111.277319. PMC 3186379. PMID 21849507.
Conde J, Scotece M, López V, Gómez R, Lago F, Pino J, Gómez-Reino JJ, Gualillo O (January 2013). "Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line". Ann. Rheum. Dis. 72 (1): 140–2. doi:10.1136/annrheumdis-2012-201693. PMID 22736092. S2CID 20772682.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000184163 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023571 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Family with sequence similarity 132, member A".

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References

Further reading