FIZ1

FIZ1
Identifiers
Aliases	FIZ1, ZNF798, FLT3 interacting zinc finger 1
External IDs	OMIM: 609133 MGI: 1344336 HomoloGene: 22663 GeneCards: FIZ1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,601,970 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	5,017,696 bp
RNA expression pattern
	Top expressed in
	ventral tegmental area; ; cardia; ; tibialis anterior muscle; ; subthalamic nucleus; ; external globus pallidus; ; body of tongue; ; inferior ganglion of vagus nerve; ; medulla oblongata; ; superior vestibular nucleus; ; pericardium;
	Top expressed in
	Bowman's capsule; ; internal carotid artery; ; medial ganglionic eminence; ; external carotid artery; ; primitive streak; ; interventricular septum; ; temporal muscle; ; secondary oocyte; ; right ventricle; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	receptor tyrosine kinase binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	positive regulation of protein phosphorylation; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	84922
	23877
	ENSG00000179943
	ENSMUSG00000061374
	Q96SL8
	Q9WTJ4
	NM_032836
NM_001110328; NM_001110329; NM_001110330; NM_011813; NM_001360241;
	NM_001360242; NM_001360243
	NP_116225
NP_001103798; NP_001103799; NP_001103800; NP_035943; NP_001347170;
	NP_001347171; NP_001347172
	Wikidata
View/Edit Human	View/Edit Mouse

FLT3 interacting zinc finger 1 is a protein that in humans is encoded by the FIZ1 gene. ^[5]

Function

This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000179943 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061374 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: FLT3 interacting zinc finger 1". Retrieved 2018-05-22.

Mitton KP, Swain PK, Khanna H, Dowd M, Apel IJ, Swaroop A (February 2003). "Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor". Hum. Mol. Genet. 12 (4): 365–73. doi:10.1093/hmg/ddg035. PMID 12566383.
Mali RS, Zhang X, Hoerauf W, Doyle D, Devitt J, Loffreda-Wren J, Mitton KP (February 2007). "FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro". Exp. Eye Res. 84 (2): 349–60. doi:10.1016/j.exer.2006.10.009. PMC 5066392. PMID 17141759.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000179943 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061374 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FLT3 interacting zinc finger 1". Retrieved 2018-05-22.

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Function

References

Further reading