First Interstate Bank may refer to:

• First Interstate Bancorp of Los Angeles, California, which merged with Wells Fargo in 1996
  • Several buildings formerly named for the bank, now known as
    • Aon Center (Los Angeles), California
      • a fire in this building on May 4, 1988 may be referred to as the First Interstate Tower fire
    • Fountain Place, Dallas, Texas
    • Library Tower, Los Angeles, CA
    • Wells Fargo Plaza (Houston), Texas
    • Wells Fargo Center (Portland, Oregon)
    • Wells Fargo Center (Seattle), Seattle, Washington
• First Interstate BancSystem, Billings, Montana bank since 1984

See also

• First Bank (disambiguation)
• First Interstate Bank Center, Redmond, Oregon