| No. 25 | |
 Seno on a 1948 Bowman football card | |
| Born: | February 15, 1921 Mendota, Illinois, U.S. |
|---|---|
| Died: | Bellwood, Illinois, U.S. |
| Career information | |
| Position(s) | Running back Defensive back |
| College | George Washington |
| Career history | |
| As player | |
| 1943–1944 | Washington Redskins |
| 1945–1946 | Chicago Cardinals |
| 1947–1948 | Boston Yanks |
| 1949 | Washington Redskins |
| Career stats | |
| |
Frank Seno (February 15, 1921 – March 1974) was an American football running back and defensive back in the National Football League (NFL) for the Washington Redskins, the Chicago Cardinals, and the Boston Yanks. He attended George Washington University.
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