G6PC1
Identifiers
AliasesG6PC1, glucose-6-phosphatase catalytic subunit, GSD1a, glucose-6-phosphatase catalytic subunit 1, GSD1, G6Pase, G6PC, G6PT
External IDsOMIM: 613742 MGI: 95607 HomoloGene: 20079 GeneCards: G6PC1
Orthologs
SpeciesHumanMouse
Entrez

2538

14377

Ensembl

ENSG00000131482

ENSMUSG00000078650

UniProt

P35575

P35576

RefSeq (mRNA)

NM_001270397
NM_000151

NM_008061

RefSeq (protein)

NP_000142
NP_001257326

NP_032087

Location (UCSC)Chr 17: 42.9 – 42.91 MbChr 11: 101.26 – 101.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glucose-6-phosphatase, catalytic subunit (glucose 6-phosphatase alpha) is an enzyme that in humans is encoded by the G6PC gene.[5][6]

Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease).[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:
GlycolysisGluconeogenesis_WP534
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GlycolysisGluconeogenesis_WP534
|alt=Glycolysis and Gluconeogenesis edit]]
Glycolysis and Gluconeogenesis edit
  1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000131482 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078650 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Brody LC, Abel KJ, Castilla LH, Couch FJ, McKinley DR, Yin G, Ho PP, Merajver S, Chandrasekharappa SC, Xu J, et al. (Jul 1995). "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17". Genomics. 25 (1): 238–47. doi:10.1016/0888-7543(95)80131-5. PMID 7774924.
  6. 1 2 "Entrez Gene: G6PC glucose-6-phosphatase, catalytic subunit".

Further reading

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