Progonadoliberin-2 is a protein that in humans is encoded by the GNRH2 gene.[1][2][3]

The protein encoded by this gene is a preproprotein that is cleaved to form a secreted 10 aa peptide hormone, QHWSHGWYPG.[4] The secreted decapeptide regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. Three transcript variants that encode unique proproteins but the same peptide hormone have been found for this gene.[3] The peptide belongs to gonadotropin-releasing hormone family.

References

  1. White RB, Eisen JA, Kasten TL, Fernald RD (Feb 1998). "Second gene for gonadotropin-releasing hormone in humans". Proc Natl Acad Sci U S A. 95 (1): 305–9. Bibcode:1998PNAS...95..305W. doi:10.1073/pnas.95.1.305. PMC 18209. PMID 9419371.
  2. Chen A, Ganor Y, Rahimipour S, Ben-Aroya N, Koch Y, Levite M (Nov 2002). "The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs". Nat Med. 8 (12): 1421–6. doi:10.1038/nm801. PMID 12447356.
  3. 1 2 "Entrez Gene: GNRH2 gonadotropin-releasing hormone 2".
  4. "GNRH2 - Progonadoliberin-2 precursor - Homo sapiens (Human) - GNRH2 gene & protein". uniprot. Retrieved 19 January 2019.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.