GRAMD4

GRAMD4
Identifiers
Aliases	GRAMD4, DIP, dA59H18.1, dJ439F8.1, GRAM domain containing 4
External IDs	OMIM: 613691 MGI: 2676308 HomoloGene: 18199 GeneCards: GRAMD4
Gene location (Human)
Chr.	Chromosome 22 (human)
End	46,679,790 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	86,021,835 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; sural nerve; ; monocyte; ; ganglionic eminence; ; left ventricle; ; skin of abdomen; ; rectum; ; anterior pituitary; ; gallbladder; ; islet of Langerhans;
	Top expressed in
	interventricular septum; ; pyloric antrum; ; epithelium of stomach; ; trigeminal ganglion; ; ganglionic eminence; ; superior cervical ganglion; ; mucous cell of stomach; ; right ventricle; ; blood; ; utricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	mitochondrial membranes; integral component of membrane; membrane; mitochondrion; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of toll-like receptor 9 signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23151
	223752
	ENSG00000075240
	ENSMUSG00000035900
	Q6IC98
	Q8CB44
	NM_015124; NM_001366660
	NM_001205353; NM_172611; NM_001379572
	NP_055939; NP_001353589
	NP_001192282; NP_766199; NP_001366501
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain containing 4 (GRAMD4) also known as Death-Inducing Protein (DIP) is a protein that is encoded by the GRAMD4 gene.^[5]^[6]

Function

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis.^[7]

1 2 3 GRCh38: Ensembl release 89: ENSG00000075240 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035900 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GRAM domain containing 4". Retrieved 2017-05-16.
↑ "RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein". Retrieved 2020-03-07.
↑ Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177. S2CID 24578301.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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