Gary H. Posner (June 2, 1943[1] – February 26, 2018[2]) was Scowe Professor of Chemistry at Johns Hopkins University in Baltimore, Maryland.[3] Posner is known for his pioneering research in organocopper chemistry, including his involvement in the development of the Corey–House–Posner–Whitesides reaction.

Career

Posner was born in New York City[1] and completed his undergraduate studies at Brandeis University. He received his PhD from Harvard University in 1968 where his adviser was E. J. Corey. He did a post-doctoral fellowship at the University of California Berkeley. He was at Johns Hopkins University from 1969 to 2016, where he held the Scowe Professorship in Chemistry from 1989 onwards.

Research

Posner was first known for his pioneering research in organocopper chemistry in which he developed novel methods for organic synthesis involving organocopper reagents.[4][5] He is the author of the textbook An Introduction to Synthesis Using Organocopper Reagents. Posner has also contributed numerous other developments in synthetic organic chemistry including asymmetric synthesis and multicomponent organic reactions.[6] Posner's recent research has been focused on applying organic synthesis to the preparation of novel medicinal agents including isothiocyanates with anticancer properties,[7] new vitamin D analogs for the treatment of psoriasis,[8][9] and new antimalarial peroxides.[10][11][12]

Awards

In 1987, Posner was named Maryland Chemist of the Year and in 1994 he received the Distinguished Teaching Award at Johns Hopkins.[3] He was also a 2004 recipient of a Cope Senior Scholar Award from the American Chemical Society.[13]

References

  1. 1 2 "GARY H. POSNER". The Robert A. Welch Foundation Research Bulletin (46): 18. 1983.
  2. ↑ Renowned chemist, longtime Hopkins faculty member Gary Posner dies at 74
  3. 1 2 Jean and Norman Scowe Professorship in Chemistry
  4. ↑ Posner, Gary H. (1972). "Conjugate Addition Reactions of Organocopper Reagents". Organic Reactions. Vol. 19. pp. 1–113. doi:10.1002/0471264180.or019.01. ISBN 978-0471264187.
  5. ↑ Posner, Gary H. (1975). "Substitution Reactions Using Organocopper Reagents". Organic Reactions. Vol. 22. pp. 253–400. doi:10.1002/0471264180.or022.02. ISBN 978-0471264187.
  6. ↑ Posner, Gary H.; Canella, Karen A.; Silversmith, Ernest F. (1988). "One-pot, three-component, sequential Michael-Michael-ring-closure reactions. Annulation of meta-dicarboxylated aromatic rings. Total synthesis of juncunol". Journal of Chemical Sciences. 100 (2–3): 81–90. doi:10.1007/BF02839442. S2CID 91965184.
  7. ↑ Posner, Gary H.; Cho, C.-G.; Green, Julianne V.; Zhang, Yuesheng; Talalay, Paul (1994). "Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes". Journal of Medicinal Chemistry. 37 (1): 170–6. doi:10.1021/jm00027a021. PMID 8289191.
  8. ↑ Posner, G; Kahraman, M (2005). Overview: rational design of 1α,25-dihydroxyvitamin D3 analogs (Deltanoids). Vol. 2. pp. 1405–1422. doi:10.1016/B978-012252687-9/50084-X. ISBN 978-0-12-252687-9. {{cite book}}: |journal= ignored (help)
  9. ↑ Guyton, Kathryn Z.; Kensler, Thomas W.; Posner, Gary H. (2004). "Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs". Cancer Chemoprevention. Vol. 1. pp. 259–274. doi:10.1007/978-1-59259-767-3_17. ISBN 978-1-61737-342-8.
  10. ↑ O'Neill, Paul M.; Posner, Gary H. (2004). "A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides". Journal of Medicinal Chemistry. 47 (12): 2945–2964. doi:10.1021/jm030571c. PMID 15163175.
  11. ↑ Posner, Gary H.; Parker, Michael H.; Northrop, John; Elias, Jeffrey S.; Ploypradith, Poonsakdi; Xie, Suji; Shapiro, Theresa A. (1999). "Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family". Journal of Medicinal Chemistry. 42 (2): 300–304. doi:10.1021/jm980529v. PMID 9925735.
  12. ↑ Posner, Gary H.; Paik, Ik-Hyeon; Chang, Wonsuk; Borstnik, Kristina; Sinishtaj, Sandra; Rosenthal, Andrew S.; Shapiro, Theresa A. (2007). "Malaria-Infected Mice Are Cured by a Single Dose of Novel Artemisinin Derivatives". Journal of Medicinal Chemistry. 50 (10): 2516–9. doi:10.1021/jm070149m. PMID 17439113.
  13. ↑ Arthur C. Cope Scholar Awards Archived 2011-08-11 at the Wayback Machine, American Chemical Society
  • Seeman, Jeffrey I. (2016). "Gary H. Posner: Professor, Scientist, Colleague, Role Model, and Friend". Tetrahedron. 72 (40): 5950–5955. doi:10.1016/j.tet.2016.06.053.
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