In gene-activated matrix technology (GAM), cytokines and growth factors could be delivered not as recombinant proteins but as plasmid genes.[1] GAM is one of the tissue engineering approaches to wound healing. Following gene delivery, the recombinant cytokine could be expressed in situ by endogenous would healing cells – in small amounts but for a prolonged period of time – leading to reproducible tissue regeneration. The matrix can be modified by incorporating a viral vector, mRNA or DNA bound to a delivery system, or a naked plasmid.[2]

References

  1. ↑ Bonadio, Jeffrey (2000). "Review: Local Gene Delivery for Tissue Regeneration". E-biomed: The Journal of Regenerative Medicine. 1 (2): 25–29. doi:10.1089/152489000414552.
  2. ↑ Krasilnikova, O.; Yakimova, A.; Ivanov, S.; Atiakshin, D.; Kostin, A.A.; Sosin, D.; Shegay, P.; Kaprin, A.D.; Klabukov, I. (2023). "Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results". International Journal of Molecular Sciences. 24 (22): 16250. doi:10.3390/ijms242216250. ISSN 1422-0067. PMC 10671237. PMID 38003439.


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