GBP6
Identifiers
Aliases	GBP6, guanylate binding protein family member 6
External IDs	OMIM: 612467 MGI: 97072 HomoloGene: 128731 GeneCards: GBP6
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.2 Start 89,364,059 bp[1] End 89,388,160 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E5|5 50.68 cM Start 105,263,633 bp[2] End 105,287,452 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cavity of mouth body of tongue superior surface of tongue thymus vulva vagina human penis bronchial epithelial cell minor salivary gland right coronary artery Top expressed in thymus spleen lung heart pancreas islet of Langerhans jejunum ileum muscle tissue ovary More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding GTPase activity Cellular component extracellular exosome symbiont-containing vacuole membrane cytoplasmic vesicle Biological process defense response to bacterium immune response cellular response to interferon-gamma defense response to protozoan defense response to Gram-positive bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 163351 17472 Ensembl ENSG00000183347 ENSMUSG00000079363 UniProt Q6ZN66 n/a RefSeq (mRNA) NM_198460 NM_001320257 NM_001256005 NM_008620 NM_001359079 NM_001359080 NM_001359081 NM_001359082 RefSeq (protein) NP_001307186 NP_940862 n/a Location (UCSC) Chr 1: 89.36 – 89.39 Mb Chr 5: 105.26 – 105.29 Mb PubMed search [3] [4]
Wikidata
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Guanylate binding protein family member 6 is a protein that in humans is encoded by the GBP6 gene. ^[5]

Function

Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.