Guay is a surname. Notable people with the surname include:
- Albert Guay (1917–1951), Canadian mass murderer
- Annie Guay (born 1985), Canadian ice hockey player
- Erik Guay (born 1981), Canadian alpine ski racer
- Florian Guay, politician in Quebec
- François Guay (born 1968), professional ice hockey centre
- Gabriel Guay (1848–1923), French painter
- Jacob Guay (born 1999), Canadian young singer
- Joseph-Philippe Guay (1915–2001), Canadian parliamentarian
- Lucie Guay (born 1958), Canadian sprint kayaker
- Monique Guay (born 1959), Quebec politician
- Paul Guay (born 1963), American professional ice hockey player
- Pierre Malcom Guay (1848–1899), physician, surgeon and political figure in Quebec
- Raynald Guay (1933–2017), Liberal party member of the Canadian House of Commons
- Rebecca Guay, artist specializing in watercolor painting and illustration
- Richard Guay (disambiguation), multiple people
- Tom Guay (born 1965), guitar player who joined White Zombie
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