HIF1AN

HIF1AN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H2K, 1H2L, 1H2M, 1H2N, 1IZ3, 1MZE, 1MZF, 1YCI, 2CGN, 2CGO, 2ILM, 2W0X, 2WA3, 2WA4, 2XUM, 2Y0I, 2YC0, 2YDE, 3D8C, 3KCX, 3KCY, 3OD4, 3P3N, 3P3P, 4AI8, 4B7E, 4B7K, 4BIO, 4JAA, 4NR1, 4Z2W, 4Z1V
Identifiers
Aliases	HIF1AN, FIH1, hypoxia inducible factor 1 alpha subunit inhibitor, hypoxia inducible factor 1 subunit alpha inhibitor, HIFAN
External IDs	OMIM: 606615 MGI: 2442345 HomoloGene: 9906 GeneCards: HIF1AN
Gene location (Human)
Chr.	Chromosome 10 (human)
End	100,559,998 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	44,564,713 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; stromal cell of endometrium; ; triceps brachii muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; islet of Langerhans; ; deltoid muscle; ; sural nerve; ; tibialis anterior muscle; ; endothelial cell;
	Top expressed in
	knee joint; ; skeletal muscle tissue; ; triceps brachii muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; tibialis anterior muscle; ; temporal muscle; ; digastric muscle; ; gastrocnemius muscle; ; extraocular muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; peptidyl-asparagine 3-dioxygenase activity; protein homodimerization activity; ankyrin repeat binding; zinc ion binding; dioxygenase activity; metal ion binding; NF-kappaB binding; Notch binding; protein binding; carboxylic acid binding; oxidoreductase activity; peptidyl-histidine dioxygenase activity; oxygen sensor activity; 2-oxoglutarate-dependent dioxygenase activity; hypoxia-inducible factor-asparagine oxygenase activity;
Cellular component	cytoplasm; nucleoplasm; perinuclear region of cytoplasm; nucleus; cytosol;
Biological process	regulation of transcription, DNA-templated; peptidyl-histidine hydroxylation; transcription, DNA-templated; peptidyl-aspartic acid hydroxylation; peptidyl-asparagine hydroxylation; positive regulation of myoblast differentiation; positive regulation of vasculogenesis; regulation of transcription from RNA polymerase II promoter in response to hypoxia; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	55662
	319594
	ENSG00000166135
	ENSMUSG00000036450
	Q9NWT6
	Q8BLR9
	NM_017902
	NM_176958
	NP_060372
	NP_795932
	Wikidata
View/Edit Human	View/Edit Mouse

Hypoxia-inducible factor 1-alpha inhibitor is a protein that in humans is encoded by the HIF1AN gene.^[5]^[6]

Interactions

HIF1AN has been shown to interact with HIF1A^[5] and Von Hippel-Lindau tumor suppressor.^[5] Additionally, asparaginyl hydroxylation of HIF1α by FIH-1 (HIF1AN) at N803 impairs its interaction with CBP/P300.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166135 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036450 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Mahon PC, Hirota K, Semenza GL (Oct 2001). "FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity". Genes Dev. 15 (20): 2675–86. doi:10.1101/gad.924501. PMC 312814. PMID 11641274.
↑ "Entrez Gene: HIF1AN hypoxia-inducible factor 1, alpha subunit inhibitor".
↑ Chen C, Lou T (2017). "Hypoxia inducible factors in hepatocellular carcinoma". Oncotarget. 8 (28): 46691–703. doi:10.18632/oncotarget.17358. PMC 5542303. PMID 28493839.

Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML (2002). "Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch". Science. 295 (5556): 858–61. Bibcode:2002Sci...295..858L. doi:10.1126/science.1068592. PMID 11823643. S2CID 24045310.
Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ (2002). "Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5367–72. Bibcode:2002PNAS...99.5367F. doi:10.1073/pnas.082117899. PMC 122775. PMID 11959990.
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ (2002). "Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family". J. Biol. Chem. 277 (29): 26351–5. doi:10.1074/jbc.C200273200. PMID 12042299.
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK (2002). "FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor". Genes Dev. 16 (12): 1466–71. doi:10.1101/gad.991402. PMC 186346. PMID 12080085.
Dann CE, Bruick RK, Deisenhofer J (2003). "Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway". Proc. Natl. Acad. Sci. U.S.A. 99 (24): 15351–6. doi:10.1073/pnas.202614999. PMC 137720. PMID 12432100.
Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ (2003). "Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha". J. Biol. Chem. 278 (3): 1802–6. doi:10.1074/jbc.C200644200. PMID 12446723.
Lee C, Kim SJ, Jeong DG, Lee SM, Ryu SE (2003). "Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau". J. Biol. Chem. 278 (9): 7558–63. doi:10.1074/jbc.M210385200. PMID 12482756.
Koivunen P, Hirsilä M, Günzler V, Kivirikko KI, Myllyharju J (2004). "Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases". J. Biol. Chem. 279 (11): 9899–904. doi:10.1074/jbc.M312254200. PMID 14701857.
Linke S, Stojkoski C, Kewley RJ, Booker GW, Whitelaw ML, Peet DJ (2004). "Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor". J. Biol. Chem. 279 (14): 14391–7. doi:10.1074/jbc.M313614200. PMID 14734545.
Kato H, Tamamizu-Kato S, Shibasaki F (2004). "Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity". J. Biol. Chem. 279 (40): 41966–74. doi:10.1074/jbc.M406320200. PMID 15280364.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ (2006). "Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14767–72. Bibcode:2006PNAS..10314767C. doi:10.1073/pnas.0606877103. PMC 1578504. PMID 17003112.
Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ (2007). "Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor". J. Biol. Chem. 282 (33): 24027–38. doi:10.1074/jbc.M704102200. PMID 17573339.
Chen C, Lou T (2017). "Hypoxia inducible factors in hepatocellular carcinoma". Oncotarget. 8 (28): 46691–703. doi:10.18632/oncotarget.17358. PMC 5542303. PMID 28493839.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166135 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036450 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11641274-5] 1 2 3 Mahon PC, Hirota K, Semenza GL (Oct 2001). "FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity". Genes Dev. 15 (20): 2675–86. doi:10.1101/gad.924501. PMC 312814. PMID 11641274.

[entrez-6] "Entrez Gene: HIF1AN hypoxia-inducible factor 1, alpha subunit inhibitor".

[pmid28493839-7] Chen C, Lou T (2017). "Hypoxia inducible factors in hepatocellular carcinoma". Oncotarget. 8 (28): 46691–703. doi:10.18632/oncotarget.17358. PMC 5542303. PMID 28493839.

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Interactions

References

Further reading