Hans Westerhoff
Hans Westerhoff in 2014
Born
Hans Victor Westerhoff

(1953-01-14) 14 January 1953[1]
Amsterdam, The Netherlands
Alma materUniversity of Amsterdam (PhD)
Scientific career
FieldsBiological thermodynamics, Systems biology[2]
Institutions
ThesisMosaic non-equilibrium thermodynamics and (the control of) biological free-energy transduction (1983)
Doctoral advisorKarel van Dam[1][3]
Websitewww.manchester.ac.uk/research/hans.westerhoff

Hans Victor Westerhoff (born 14 January 1953 in Amsterdam, Netherlands)[1] is a Dutch biologist and biochemist who is professor of synthetic systems biology at the University of Amsterdam[4] and AstraZeneca professor of systems biology at the University of Manchester.[2] Currently he is a Chair of AstraZeneca and a director of the Manchester Centre for Integrative Systems Biology.[5][6]

Career

Westerhoff was educated at the University of Amsterdam where he was awarded a PhD in 1983 for investigations of non-equilibrium thermodynamics and the control of biological thermodynamics supervised by Karel van Dam.[1] In 1996 he succeeded Ad Stouthamer as professor of microbiology at the Vrije Universiteit Amsterdam.[7]

Research

At the beginning of his career Westerhoff worked in the area of non-equilibrium thermodynamics in relation to biological energy transduction.[8][9] His work on this topic led to a book written with Karel Van Dam.[10]

After being a coauthor of one of the first experimental papers to stimulate interest in metabolic control analysis[11] and participating in the group that proposed a harmonized terminology,[12] Westerhoff moved progressively towards working on multi-enzyme systems as his major activity, starting with an analysis of the effect of enzyme activity on metabolite concentrations.[13] He published many papers in this area, of which one may note an analysis of the control of regulatory cascades,[14] analysqis of glycolytic oscilations in yeast,[15] and showing that the in vivo behaviour of Trypanosoma brucei agreed with the kinetic properties of the glycolytic enzymes.[16]

Westerhoff and colleagues discovered magainin in the African clawed frog which helps it fight against bacteria.[17] In December 1996 he and his group discovered a nitric-oxide reductase of Paracoccus denitrificans.[18]

In conjunction with many other workers Westerhoff used a community approach to construct a consensus yeast metabolic network[19] and subsequently applied the same approach to human metabolism.[20]

References

  1. 1 2 3 4 Prof. dr. H.V. Westerhoff, 1953- at the University of Amsterdam Album Academicum website
  2. 1 2 "Hans Westerhoff". Google Scholar. Archived from the original on December 18, 2013. Retrieved December 9, 2013.
  3. ↑ Academic Tree: Karel van Dam, Amsterdam
  4. ↑ "Prof. Dr. H.V. (Hans) Westerhoff". University of Amsterdam. Archived from the original on December 12, 2013. Retrieved December 9, 2013.
  5. ↑ "Professor Hans Westerhoff". University of Manchester. Archived from the original on December 15, 2013. Retrieved December 9, 2013.
  6. ↑ Hans Westerhoff's publications indexed by the Scopus bibliographic database. (subscription required)
  7. ↑ Martine Zuidweg (11 June 1997). "De confrontatie" (in Dutch). Trouw. Retrieved 19 July 2020.
  8. ↑ Van der Meer, R; Westerhoff, H V; Van Dam, K (1980). "Linear relation between rate and thermodynamic force in enzyme-catalyzed reactions". Biochim. Biophys. Acta. 591 (2): 488–493. doi:10.1016/0005-2728(80)90179-6. PMID 7397133.
  9. ↑ Westerhoff, H V; Hellingwerf, K J; Arents, J C; Scholte, B J; Van Dam, K (1981). "Mosaic non-equilibrium thermodynamics describes biological energy transduction". Proc. Natl. Acad. Sci. USA. 78 (1): 3554–3558. Bibcode:1981PNAS...78.3554W. doi:10.1073/pnas.78.6.3554. PMC 319608. PMID 6267598.
  10. ↑ Westerhoff, H V; Van Dam, K (1987). Thermodynamics and Control of Biological Free-Energy Transduction. Elsevier. ISBN 978-0-444-80783-0.
  11. ↑ Groen, AK; Wanders, RJA; Westerhoff, HV; van de Meer, R; Tager, JM (1982). "Quantification of the contribution of various steps to the control of mitochondrial respiration". Journal of Biological Chemistry. 257 (6): 2754–2757. doi:10.1016/S0021-9258(19)81026-8. PMID 7061448.
  12. ↑ Burns, J.A.; Cornish-Bowden, A.; Groen, A.K.; Heinrich, R.; Kacser, H.; Porteous, J.W.; Rapoport, S.M.; Rapoport, T.A.; Stucki, J.W.; Tager, J.M.; Wanders, R.J.A.; Westerhoff, H.V. (1985). "Control analysis of metabolic systems". Trends Biochem. Sci. 10: 16. doi:10.1016/0968-0004(85)90008-8.
  13. ↑ Westerhoff, Hans V.; Chen, Yi-Der (1984). "How do enzyme activities control metabolite concentrations? An additional theorem in the theory of metabolic control". Eur. J. Biochem. 142 (2): 425–430. doi:10.1111/j.1432-1033.1984.tb08304.x. PMID 6745283.
  14. ↑ Kahn, D; Westerhoff, H.V. (1991). "Control theory of regulatory cascades". J. Theor. Biol. 153 (2): 255–285. Bibcode:1991JThBi.153..255K. doi:10.1016/S0022-5193(05)80426-6. PMID 1686290.
  15. ↑ Bier, M; Bakker, B. M.; Westerhoff, H. V. (2000). "How yeast cells synchronize their glycolytic oscillations: A perturbation analytic treatment". Biophys. J. 78 (3): 1087–93. Bibcode:2000BpJ....78.1087B. doi:10.1016/S0006-3495(00)76667-7. PMC 1300712. PMID 10692299.
  16. ↑ Bakker, B M; Michels, P A M; Opperdoes, F R; Westerhoff, H V (1997). "Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes". J. Biol. Chem. 272 (6): 3207–3215. doi:10.1074/jbc.272.6.3207. PMID 9013556.
  17. ↑ Westerhoff, H. V.; Zasloff, M.; Rosner, J. L.; Hendler, R. W.; Waal, A.; Gomes, A. V.; Jongsma, A. P. M.; Riethorst, A.; Juretic, D. (1995). "Functional Synergism of the Magainins PGLa and Magainin-2 in Escherichia coli, Tumor Cells and Liposomes" (PDF). European Journal of Biochemistry. 228 (2): 257–64. doi:10.1111/j.1432-1033.1995.0257n.x. PMID 7705337.
  18. ↑ Boer, A. P. N.; Oost, J.; Reijnders, W. N. M.; Westerhoff, H. V.; Stouthamer, A. H.; Spanning, R. J. M. (1996). "Mutational Analysis of the nor Gene Cluster which Encodes Nitric-Oxide Reductase from Paracoccus denitrificans". European Journal of Biochemistry. 242 (3): 592–600. doi:10.1111/j.1432-1033.1996.0592r.x. PMID 9022686.
  19. ↑ Herrgård, M. J.; Swainston, N.; Dobson, P.; Dunn, W. B.; Arga, K. Y. I.; Arvas, M.; Blüthgen, N.; Borger, S.; Costenoble, R.; Heinemann, M.; Hucka, M.; Le Novère, N.; Li, P.; Liebermeister, W.; Mo, M. L.; Oliveira, A. P.; Petranovic, D.; Pettifer, S.; Simeonidis, E; Smallbone, K; Spasic, I; Weichart, D.; Brent, R.; Broomhead, D. S.; Westerhoff, H. V.; Kirdar, B. L.; Penttilä, M.; Klipp, E.; Palsson, B. Ø.; Sauer, U.; Oliver, S. G.; Mendes, P.; Nielsen, J.; Kell, D.B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology". Nature Biotechnology. 26 (10): 1155–1160. doi:10.1038/nbt1492. PMC 4018421. PMID 18846089.
  20. ↑ Thiele, I; Swainston, N; Fleming, R M T; Hoppe, A; Sahoo, S; Aurich, M K; Haraldsdottir, H; Mo, M L; Rolfsson, O; Stobbe, M D; Thorleifsson, S G; Agren, R; Bolling, C; Bordel, S; Chavali, A K; Dobson, P; Dunn, W B; Endler, L; Hala, D; Hucka, M; Hull, D; Jameson, D; Jonsson, J J; Juty, N; Keating, S; Nookaew, I; Le Novère, N; Malys, N; Mazein, A; Papin, J A; Price, N D; Selkov, E; Sigurdsson, M I; Simeonidis, E; Sonnenschein, N; Smallbone, K; Sorokin, A; van Beek, J H G M; Weichart, D; Goryanin, I; Nielsen, J; Westerhoff, H V; Kell, D B; Mendes, P; Palsson, B O (2013). "A community-driven global reconstruction of human metabolism". Nature Biotechnology. 31 (5): 419–425. doi:10.1038/nbt.2488. PMC 3856361. PMID 23455439.
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