Main

• Maria Lourdes "Marilu" da Silva (voiced by Iara Riça) - Pepe's best friend and partner. She assists Pepe in his supernatural adventures, often getting the group into more trouble before saving the day. She has a crush on Pepe and Mario.
• Peperoni Von "Pepe" Kittenberg III (voiced by Charles Emmanuel) - A troublemaker and rude boy with spiky red hair who works as a delivery boy for his grandmother. He is always getting into mischief and causing problems, facing all the monsters and mythical beings that appear in his town, almost always through his fault. Pepe's friends are Marilu, Guto, Gastón and Roberto who often follow in the supernatural adventures.
• Ramona Bravaria de Lemornio "Vó" Peperonito (voiced by Nádia Carvalho) - Pepe's grandmother with whom he lives in his dark mansion. She is a wicked old witch who lives experimenting with their cats and sells potions using his grandson as a delivery boy. In one episode it is revealed that she is the older sister of Lady Death.
• Guterico "Guto" Flores and Gaston de la Fleur (voiced by Oberdan Junior and Luis Sérgio Vieira) - Conjoined twin brothers who have two heads together on the same body. Guto tends to be nicer while Gaston is mean and rude.
• Beto "Roberto" Massa (voiced by Charles Emmanuel and Rodrigo Antas) - A tall, muscular boy. He studies in the same room with Pepe and his friends despite being slightly larger than them. He is always dressed in a varsity jacket and has a quiff.

Recurring

• Ramirez - Pepe's pet dog. Ramirez lives with Pepe and Grandma in the mansion, sometimes coming to be of aid to Pepe. Ramirez is black with a white face that resembles the members of the band Kiss.
• Mario (voiced by Luis Sérgio Vieira) - A classmate of Pepe who normally behaves like an opposite of him. He is a smart and polite boy, but his classmates never take him seriously.
• Ritinha - Another classmate of Pepe and his friends. She is a poor, short-sighted girl who has huge glasses and is quite naive.
• The Cats - They are Pepe's grandmother's servants. They work helping her or serving as guinea pigs in the preparation of potions and sometimes they are butlers.
• The Mayor - The mayor of the city who is a living puppet controlled by his bodyguard who carries him everywhere. He has a tyrannical son called Tchithero.
• Cacá - A minor boy who is a classmate of Pepe and his friends. He rarely appears or speaks and has a strange hole in his head with a pair of eyes inside.
• Santa Claus - Christmas figure who is responsible for delivering gifts to well-behaved children and coal to naughty children. He is an old friend of Pepe's grandmother.
• Pandora - A one-time character, a serious and astute girl who frequently changes schools and carries with her a lunch box in which a shadow that represents all evil inhabits. Pepe has a platonic and reciprocated love for her.

Antagonists

• Vanda/Loira do Banheiro - An evil woman who had her spirit trapped in a mirror in a women's bathroom. She tricks girls into turning them into dolls and adding them to her collection. She was Granny's enemy in high school and got trapped in the mirror by one of her spells. She is based on the Brazilian urban legend of the same name inspired by the Bloody Mary.
• Morte - A personification of death who is Pepe's grandmother's younger sister. She has the appearance of an attractive red-haired young woman who is a biker and often go through portals to find and take the dead. She has a rivalry with her older sister in addition to being dyslexic, often confusing what she is going to say.
• Pepita - An evil female counterpart of Pepe after he put a magical wig that took over his body, her initial goal was to force her friends to like the girl show "Unicórnias Princesas", which Pepe secretly watches. She returns in season two helping to defeat the evil Marilus.
• Jack Hunter - A ruthless monster hunter who has a strong hatred and prejudice against monsters. Originally a host of a TV show Pepe adored, he constantly hunted down and trapped all the monsters he encountered until Pepe discovered that Jack was the real villain who hated monsters just for existing.
• Homem-Anta - Literally "Tapir Man", is a mysterious student at the school Pepe and his friends attend. He lives in a prison-like detention room area and has never been seen without his mask. He is jealous of the other students and always sneaks out on photo day to ruin their appearances.
• The Devil - The boss of hell and prince of darkness. Despite being considered evil, he is portrayed as a sensitive and suffering man who tries to be a good person. He constantly arranges things for people in exchange for their souls.
• Sérgio - A mutated turtle that was previously Mario's pet turtle. He was turned into a mutant by Pepe using one of his grandmother's machines in an attempt to turn him into a nice guy, but ended up accidentally turning him into a sensitive, authoritarian and annoying adult. It has 3 clones that together make a parody of the Teenage Mutant Ninja Turtles.
• Kumo Tatchi - A spirit of a Japanese masseuse who has the ability to create small ghosts by massaging each person, leaving them so calm and carefree that they can't do anything else. She has a dream of becoming a karaoke singer, despite having a terrible voice.
• Bhutumu - A gargantuan monster who appeared during the final episode of the first season. He's said to be the one who will bring the apocalypse to the earth, however it was only a bedtime story Grandmother told her grandson, teaching him that he should finish anything he started. Bhutumu is based on Cthulhu.
• Vó and Morte's parents - An immortal couple who have appearances similar to black and white 1930s cartoons and speak in European Portuguese. The mother does not have a good relationship with her daughter being extremely strict and rejecting the fact that she became a witch, despite hiding that she was also a witch.
• Zalatristhe - An intellectual and lonely zombie who has vast intelligence from all the brains he has eaten over the years, but regrets having such intelligence that it prevents him from being happy.
• Evil Marilus - Two versions of Marilu that exist inside her and represent all the hidden evil feelings hidden inside her, one represents her rude side and the other her aggressive side. They free themselves after Marilu finds a house of magic mirrors and take her place, but they return to the mirror with the help of Pepita. In an alternate future it is revealed that they return as dictators.

Pilot

Season 1 (2013)

Season 2 (2015)