Helen R. Donis-Keller
Alma materHarvard University
Scientific career
InstitutionsOlin College of Engineering
ThesisEnzymatic RNA sequencing and fractionation methods (1979)

Helen Donis-Keller is the Michael E. Moody Professor and Professor of Biology and Art at Olin College of Engineering in Needham, Massachusetts.

Education and career

Donis-Keller has a B.Sc. and an H.B.Sc. from Lakehead University. She earned her Ph.D. at Harvard University under the direction of Walter Gilbert in 1979.[1] After employment at the biotechnology companies Biogen and Collaborative Research, she joined the faculty at Washington University School of Medicine.[2][3] In 2001, she earn an MFA in studio art from the School of the Museum of Fine Arts in Boston and Tufts University and she joined the faculty at the Olin College of Engineering.[1] In 2012, she was named the Michael. E. Moody Faculty Chair.[4]

Research

Donis-Keller's graduate research established a method to do RNA sequencing.[5][6][7] During her time at Collaborative Research, her research group created the first genetic map of the human genome.[8] Donis-Keller was unable to secure either NIH or venture funding for generating the RFLP map, but convinced Collaborative Research's management to fund the project.[9][10] She continued to work on the genetic linkage map[11] and led research into understanding the genetic basis of cystic fibrosis,[12] thyroid cancer,[13] and breast cancer.[14][15]

Selected publications

  • Donis-Keller, Helen; Maxam, Allan M.; Gilbert, Walter (1977). "Mapping adenines, guanines, and pyrimidines in RNA". Nucleic Acids Research. 4 (8): 2527–2538. doi:10.1093/nar/4.8.2527. ISSN 0305-1048. PMC 342589. PMID 409999.
  • Doniskeller, H (October 1987). "A genetic linkage map of the human genome". Cell. 51 (2): 319–337. doi:10.1016/0092-8674(87)90158-9. ISSN 0092-8674. PMID 3664638. S2CID 7230640.
  • Donis-Keller, Helen; Dou, Shenshen; Chi, David; Carlson, Katrin M.; Toshima, Koji; Lairmore, Terry C.; Howe, James R.; Moley, Jeffrey F.; Goodfellow, Paul; Wells, Samuel A. (1993). "Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC". Human Molecular Genetics. 2 (7): 851–856. doi:10.1093/hmg/2.7.851. ISSN 0964-6906. PMID 8103403.

Awards

  • Doctor of Science Degree (Honoris Causa) from Lakehead University (1995)[16]

Art

In addition to teaching art at Olin,[2] Donis-Keller is herself an artist, and her art can be seen at Needham's 2021 Open Studios event[17] and other venues.[18][19][20] Her Ph.D. advisor, Walter Gilbert, has also begun to investigate the intersection between art and science though, in a 2015 interview, Donis-Keller did not recall his interest in art while she was a student in his lab.[21]

References

  1. 1 2 "Helen Donis-Keller | Art, Science, and Education". Retrieved 2021-09-26.
  2. 1 2 "Faculty Profile for Helen Donis-Keller, Ph.D. | Olin College of Engineering". www.olin.edu. Retrieved 2021-09-26.
  3. ↑ "Committee Biographies". Assessing Genetic Risks: Implications for Health and Social Policy: Committee Biographies. National Academies Press (US). 1994.
  4. ↑ "Olin College Names Professor Helen Donis-Keller as Inaugural Holder of the Michael E. Moody Chair". PRWeb. December 20, 2012. Retrieved 2021-09-27.
  5. ↑ Donis-Keller, Helen; Maxam, Allan M.; Gilbert, Walter (1977). "Mapping adenines, guanines, and pyrimidines in RNA". Nucleic Acids Research. 4 (8): 2527–2538. doi:10.1093/nar/4.8.2527. ISSN 0305-1048. PMC 342589. PMID 409999.
  6. ↑ Donis-Keller, Helen (1979). "Site specific enzymatic cleavage of RNA". Nucleic Acids Research. 7 (1): 179–192. doi:10.1093/nar/7.1.179. ISSN 0305-1048. PMC 328004. PMID 386279.
  7. ↑ Donis-Keller, Helen (1980). "Phy M: an RNase activity specific for U and A residues useful in RNA sequence analysis". Nucleic Acids Research. 8 (14): 3133–3142. doi:10.1093/nar/8.14.3133. ISSN 0305-1048. PMC 324360. PMID 6160466.
  8. ↑ Donis-Keller, Helen; Green, Phillip; Helms, Cynthia; Cartinhour, Samuel; Weiffenback, Barbara; Stephens, Karen; Keith, Tim P.; Bowden, Donald W. (October 23, 1987). "A Genetic Linkage Map of the Human Genome" (PDF). Cell. 51 (2): 319–337. doi:10.1016/0092-8674(87)90158-9. PMID 3664638. S2CID 7230640.
  9. ↑ Cook-Deegan, Robert (1996). The Gene Wars: Science, Politics and the Human Genome. W. W. Norton & Company. ISBN 9780393313994.
  10. ↑ Robert Mullan Cook-Deegan; Hanna, Kathi E. (1991). The Human Genome Project: The Formation of Federal Policies in the United States, 1986-1990. National Academies Press (US).
  11. ↑ Group, NIH/CEPH Collaborative Mapping (1992). "A Comprehensive Genetic Linkage Map of the Human Genome". Science. 258 (5079): 67–86. doi:10.1126/science.1439770. ISSN 0036-8075. JSTOR 2885812.
  12. ↑ Roberts, Leslie (1988). "The Race for the Cystic Fibrosis Gene". Science. 240 (4849): 141–144. Bibcode:1988Sci...240..141R. doi:10.1126/science.3281257. ISSN 0036-8075. JSTOR 1701223. PMID 3281257.
  13. ↑ Donis-Keller, Helen; Dou, Shenshen; Chi, David; Carlson, Katrin M.; Toshima, Koji; Lairmore, Terry C.; Howe, James R.; Moley, Jeffrey F.; Goodfellow, Paul; Wells, Samuel A. (1993). "Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC". Human Molecular Genetics. 2 (7): 851–856. doi:10.1093/hmg/2.7.851. ISSN 0964-6906. PMID 8103403.
  14. ↑ Radford, Diane M.; Fair, Keri L.; Phillips, Nancy J.; Ritter, Jon H.; Steinbrueck, Todd; Holt, Matthew S.; Donis-Keller, Helen (1995-08-01). "Allelotyping of Ductal Carcinoma in Situ of the Breast: Deletion of Loci on 8p, 13q, 16q, 17p and 17q". Cancer Research. 55 (15): 3399–3405. ISSN 0008-5472. PMID 7614479.
  15. ↑ Glass, Andrew G.; Donis-Keller, Helen; Mies, Carolyn; Russo, Jose; Zehnbauer, Barbara; Taube, Sheila; Aamodt, Roger (2001-07-01). "The Cooperative Breast Cancer Tissue Resource: Archival Tissue for the Investigation of Tumor Markers". Clinical Cancer Research. 7 (7): 1843–1849. ISSN 1078-0432. PMID 11448894.
  16. ↑ "Past Honorary Degrees". Lakehead University. Retrieved 2021-09-26.
  17. ↑ CULTURE, COURTESY OF NEEDHAM COUNCIL FOR ARTS AND. "Needham students, artists showcase presentations with Storefronts Needham". Wicked Local. Retrieved 2021-09-27.
  18. ↑ "How Genomic - Helen Donis-Keller". www.jgsinc.org. Retrieved 2021-09-27.
  19. ↑ "Helen Donis-Keller – Krakow Witkin Gallery". Retrieved 2021-09-27.
  20. ↑ "HELEN DONIS-KELLER, MFA 01 - Hero of the Earth, Havana - $700". smfa.bidsquare.com. Archived from the original on 2021-09-27. Retrieved 2021-09-27.
  21. ↑ Johnson, Carolyn Y. (March 13, 2015). "A physicist, biologist, Nobel laureate, CEO, and now, artist - The Boston Globe". BostonGlobe.com. Retrieved 2021-09-27.
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