Human betaherpesvirus 6A
Virus classification Edit this classification
(unranked): Virus
Realm: Duplodnaviria
Kingdom: Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family: Orthoherpesviridae
Genus: Roseolovirus
Species:
Human betaherpesvirus 6A
Synonyms

Human herpesvirus 6

Human betaherpesvirus 6A (HHV-6A) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1]

HHV-6A and infertility

  • A 2016 study showed that 43% of women with unexplained infertility tested positive for HHV-6A while 0% of women in the fertile control group tested positive. HHV-6A was found present in endrometrial epithelial cells from women with unexplained infertility. [2]
  • A 2018 study reports the prevalence of HHV-6A in endometrial biopsies among women experiencing recurrent implantation failure after IVF/ET compared to control groups.[3]
  • A 2019 study confirmed the presence of HHV-6A infection in 40% of idiopathic infertile women. Identifying the effect of HHV-6A infection on endometrial immune status opens up a new perspectives on ferility care. Its possible to choose antiviral therapies and non-hormonal approaches for women with unexplained infertility characterized by HHV-6A to increase their pregnancy rate.[4]

Taxonomy

In 1992 the two variants were recognised within Human herpesvirus 6 on the basis of differing restriction endonuclease cleavages, monoclonal antibody reactions,[5] and growth patterns.[6] In 2012 these two variants were officially recognised as distinct species by the International Committee on Taxonomy of Viruses and named Human betaherpesvirus 6A and Human betaherpesvirus 6B.[7] Despite now being recognised as paraphyletic, the name Human herpesvirus 6 still sees usage in clinical contexts.

Pathology

Human betaherpesvirus 6A affects humans and includes several adult-derived strains. Its disease spectrum is not well defined, although it is thought by some to be more neurovirulent than Human betaherpesvirus 6B.[8][9]

References

  1. ↑ "ICTV Master Species List 2018b.v2". International Committee on Taxonomy of Viruses (ICTV). Archived from the original on March 30, 2019. Retrieved 19 June 2019.
  2. ↑ Marci R, Gentili V, Bortolotti D, Lo Monte G, Caselli E, Bolzani S, et al. (2016-07-01). "Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility". PLOS ONE. 11 (7): e0158304. Bibcode:2016PLoSO..1158304M. doi:10.1371/journal.pone.0158304. PMC 4930213. PMID 27367597.
  3. ↑ Coulam CB, Bilal M, Salazar Garcia MD, Katukurundage D, Elazzamy H, Fernandez EF, et al. (July 2018). "Prevalence of HHV-6 in endometrium from women with recurrent implantation failure". American Journal of Reproductive Immunology. 80 (1): e12862. doi:10.1111/aji.12862. PMID 29667291. S2CID 4944870.
  4. ↑ Bortolotti D, Gentili V, Rotola A, Cultrera R, Marci R, Di Luca D, Rizzo R (October 2019). "HHV-6A infection of endometrial epithelial cells affects immune profile and trophoblast invasion". American Journal of Reproductive Immunology. 82 (4): e13174. doi:10.1111/aji.13174. hdl:11392/2406194. PMID 31338899. S2CID 198193327.
  5. ↑ Kawabata A, Oyaizu H, Maeki T, Tang H, Yamanishi K, Mori Y (December 2011). "Analysis of a neutralizing antibody for human herpesvirus 6B reveals a role for glycoprotein Q1 in viral entry". Journal of Virology. 85 (24): 12962–12971. doi:10.1128/JVI.05622-11. PMC 3233151. PMID 21957287.
  6. ↑ Braun DK, Dominguez G, Pellett PE (July 1997). "Human herpesvirus 6". Clinical Microbiology Reviews. 10 (3): 521–567. doi:10.1128/CMR.10.3.521. PMC 172933. PMID 9227865.
  7. ↑ Adams MJ, Carstens EB (July 2012). "Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012)". Archives of Virology. 157 (7): 1411–1422. doi:10.1007/s00705-012-1299-6. PMC 7086667. PMID 22481600.
  8. ↑ Kofman A, Marcinkiewicz L, Dupart E, Lyshchev A, Martynov B, Ryndin A, et al. (December 2011). "The roles of viruses in brain tumor initiation and oncomodulation". Journal of Neuro-Oncology. 105 (3): 451–466. doi:10.1007/s11060-011-0658-6. PMC 3278219. PMID 21720806.
  9. ↑ Arbuckle JH, Medveczky MM, Luka J, Hadley SH, Luegmayr A, Ablashi D, et al. (March 2010). "The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro". Proceedings of the National Academy of Sciences of the United States of America. 107 (12): 5563–5568. Bibcode:2010PNAS..107.5563A. doi:10.1073/pnas.0913586107. PMC 2851814. PMID 20212114.
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