Huygens (also Huijgens, Huigens, Huijgen/Huygen, or Huigen) is a Dutch patronymic surname, meaning "son of Hugo". Most references to "Huygens" are to the polymath Christiaan Huygens. Notable people with the surname include:
- Jan Huygen (1563–1611), Dutch voyager and historian
 - Constantijn Huygens (1596–1687), Dutch poet, diplomat, scholar and composer
 - Constantijn Huygens, Jr. (1628–1697), Dutch statesman, soldier, and telescope maker, son of Constantijn Huygens
 - Christiaan Huygens (1629–1695), Dutch mathematician, physicist and astronomer, son of Constantijn Huygens
 - Lodewijck Huygens (1631–1699), Dutch diplomat, the third son of Constantijn Huygens
 - Cornélie Huygens (1848–1902), Dutch writer, social democrat and feminist
 - Léon Huygens (1876–1918), Belgian painter
 - Jan Huijgen (1888–1964), Dutch speedwalker
 - Christiaan Huijgens (1897–1963), Dutch long-distance runner
 - Wil Huygen (1922–2009), Dutch children's and fantasy writer, e.g. of Gnomes
 
Named after Constantijn Sr
- Constantijn Huygens Prize, Dutch literary award
 - Huygens Institute for Dutch History
 
Named after Christiaan Huygens
Astronomy:
- Cassini–Huygens, mission to Saturn and Titan
- Huygens (spacecraft), the probe of above mission which landed on Saturn's moon Titan in 2005
 
 - 2801 Huygens, an asteroid
 - Huygens (crater), a Martian crater
 - Mons Huygens, a mountain of Earth's Moon
 - Huygens Gap, main gap in the rings of Saturn
 
Physics:
- Huygens' principle regarding wave propagation
 - Huygens law regarding pendulums
 - Huygens–Steiner theorem regarding moment of inertia
 
Mathematics and games:
- Huygens' tritone, a musical interval
 - Huygens lemniscate, a figure eight curve
 
Microscopes:
- Huygens eyepiece, first compound eye piece
 - Huygens Software, a microscope image processing package
 
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